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Metformin enhances the cellular response to insulin and influences metabolism, which contributes to decreased accumulation of senescent cells.
Additionally, metformin activates the AMP-activated protein kinase (AMPK) pathway, which not only improves insulin sensitivity but also helps lower blood sugar levels and has various other health benefits.
* Metformin is not FDA-approved for the treatment of longevity or anti-aging purposes. Learn more about ‘off-label’ uses.
* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.
* Common side effects of Metformin include nausea, diarrhea, stomach pain, bloating, gas, indigestion, or a metallic taste in the mouth. Do not take Metformin if you are allergic to it, have severe kidney disease, metabolic acidosis, or diabetic ketoacidosis.
* Call your doctor immediately if you have symptoms of lactic acidosis such as muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Metformin, a drug initially approved for treating type 2 diabetes, was first synthesized in the 1920s and has since been widely used to manage blood sugar levels. Beyond its primary medical application, metformin is now being explored for its potential in promoting longevity.
Research has shown that it can influence aging-related mechanisms, largely due to its ability to activate the AMP-activated protein kinase (AMPK) pathway, which plays a crucial role in cellular energy homeostasis. This has sparked interest in its use as a therapeutic intervention against age-associated diseases and conditions.
Widely regarded by health and science communities, including features in major publications, metformin is gaining recognition as a promising agent in the field of aging and longevity research.
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities.
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Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities.
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