US clinician prescribed Rapamycin.

Studies have indicated that Rapamycin can increase the lifespan of various organisms, such as yeast, nematodes, fruit flies, and mice. It is believed that rapamycin imitates the benefits of caloric restriction, which has been shown to enhance lifespan in numerous species.

The longevity effects of rapamycin are thought to be a result of its ability to inhibit mTOR, which in turn triggers autophagy, reduces inflammation and cellular senescence, and enhances immune function.

See a clinician and get your prescription ordered today.

* Rapamycin is not FDA-approved for the treatment of longevity or anti-aging purposes. Learn more about ‘off-label’ uses.

* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.

* Common side effects of Rapamycin include mouth sores, diarrhea, joint pain, acne, headache, or increased risk of infection. Do not take Rapamycin if you are allergic to it, have liver disease, or have a history of lung or breathing problems.

* Call your doctor immediately if you have symptoms of an allergic reaction such as rash, itching, swelling, severe dizziness, trouble breathing, or symptoms of serious infections.


Rapamycin is a naturally extracted compound found in 1972 on Rapa Nui (Easter Island), which is where it gets its name. It has been used to help the body to accept transplants, to treat lung disease and to treat coronary stents.

It is now being researched as a longevity focused intervention. Since a groundbreaking 2014 experiment showed it could extend the lifespan of mice by 14%, it has been studied for its effect on age related disease and life extension.

The Washington Post, called it a “darling of longevity enthusiasts”, while GQ asked “is the secret to a longer life already available at your local pharmacy?”

How a cheap, generic drug became a darling of longevity enthusiasts

To keep himself healthy into his eighth decade, David Sandler recently decided to go beyond his regular workouts and try something experimental: taking rapamycin, an unproven but increasingly popular drug to promote longevity.

Rapamycin: The unlucky history of the most powerful anti-aging drug

In 1972, scientists discovered rapamycin, a compound initially thought to have antifungal properties, in a soil sample from Easter Island. The researchers soon discovered that it had unprecedented anti-cancer activity. 

Is the Secret to a Longer Life Already Available at Your Local Pharmacy?

Depending on who you ask, we may be on the cusp of a great leap forward in longevity medicine. “In probably the next three to four years, you will have this pill basket” of anti-aging drugs, says Dr. Vijay Yadav, an assistant professor of genetics and development…

Rapamycin's Anti-Aging Effects Have Scientists Calling It the 'Longevity Drug'

Humans are living longer than ever before, but that doesn’t mean we’re living better. As we age, people have less energy, are more prone to falls and serious injuries, and infections become harder to recover from. 

Could a Drug Give Your Pet More Dog Years?

The life of a pet dog follows a predictable trajectory. Over time, the floppy-eared puppy that keeps falling asleep in his food bowl will become a lanky-legged adolescent with an insatiable interest in squirrels — before eventually settling into adulthood as a canine…

Could rapamycin be our next weapon in the fight for longevity?

Life expectancy has increased steadily over the past 200 years, and along with it, the incidence of age-related disease. While lifespan has increased, the so-called healthspan has not kept pace.

Long-lasting geroprotection from brief rapamycin treatment in early adulthood...

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment…

Evaluation of off-label rapamycin use to promote healthspan in 333 adults

Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and healthspan metrics in yeast, invertebrates, and rodents. 

Anti-aging drug rapamycin improves immune function through endolysosomes

Rapamycin is considered a promising anti-aging drug that improves health in old age and alleviates the age-related decline in immune function. A research group at the Max Planck Institute for Biology of Ageing has discovered in fruit flies that rapamycin…

Rapamycin is a potential anti-ageing drug

If you like the idea of living as long as possible, rapamycin may be the drug for you. Originally developed as an immunosuppressant for organ transplant patients, it has found a new lease on life as a potential anti-ageing drug. 

Longevity Direct

Longevity 360​°

  • INCLUSIVE - Personal Guidance - advice from clinicians, longevity specialists to get answers from experts.
  • FREE - blēo band (RRP $149) - packed with sensors to track millions of longevity signals, from blood oxygen to stress.
  • FREE - The Longevity AI - personalized longevity coaching trained on leading longevity research.
  • Lab Testing - A combination of blood and salvia tests and our AI enhanced platform we can open up actionable insights into your body and your specific longevity needs.
  • DISCOUNTED - Saints One - the world's most powerful non-prescription longevity supplement program.

Science & Research

How to order

Ordering takes just three simple steps.

Answer a few questions

Click 'Get Started' and we'll ask a few quick questions.

Online consultation

Select an online appointment with one of our partner US physicians.

Delivered to you

We'll coordinate shipping each month at no extra cost.

Complete Patient Intake Form

Continue Browsing Our Offers