In the pursuit of longevity, biomarkers play a crucial role in assessing an individual’s overall health and predicting their lifespan. Bicarbonate, a key marker of acid-base balance, has garnered attention for its potential association with longevity. Maintaining optimal bicarbonate levels can indicate proper kidney function and metabolic health, both of which are essential for longevity. Elevated bicarbonate levels have been linked to increased longevity in some studies, suggesting its potential as a biomarker for assessing overall health and predicting lifespan. Monitoring and optimizing bicarbonate levels may offer valuable insights into an individual’s potential for longevity and overall health.