Physician-prescribed GLP-1 Program

Lose weight with a physician behind you.Real results. Real support. No guesswork.

A physician-supervised GLP-1 protocol at therapeutic doses.
What patients report:

  • Meaningful, sustained weight loss from week one
  • Physician-adjusted dosing based on your lab results
  • 50+ biomarkers tracked to protect your health while you lose
  • Muscle-preserving protocol with body composition monitoring
$179
First month, then $299/mo
Cancel anytime
GLP-1 wellness protocol

AS FEATURED IN

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My physician reviewed my labs before adjusting anything. That level of care is why I'm still here six months later.David M.

4.9/5
500+ patients

The power of GLP-1 Therapy

0lbs

Average weight lost in the first 12 weeks on physician-supervised GLP-1.*

0%

Of patients report sustained weight loss at six months.*

*Based on patient-reported outcomes.

Is GLP-1 Therapy right for me?

This protocol is designed for people who want meaningful, physician-supervised weight loss with full metabolic oversight.

Selected: Lose weight without sacrificing muscle

Patient maintaining strength while losing weight

I've lost about 14 pounds over four months. At the same time I've been able to increase my muscle mass. I didn't expect to keep both.

Sarah, 48

GLP-1 Program since Sep '24

From first assessment to optimized protocol, entirely online

No waiting rooms. No referrals. A physician-supervised protocol built around your data.

Complete your health assessment
Step 1

Complete your health assessment

A brief intake covering your health history, goals, and current medications.

GLP-1 therapy medication

The GLP-1 Protocol

At therapeutic doses, GLP-1 drives significant fat reduction, improves insulin sensitivity, and reduces chronic inflammation. Your physician monitors your full metabolic picture to ensure you're losing weight safely.

Clinically Meaningful Weight Loss

Therapeutic-dose GLP-1 reduces appetite, increases satiety, and shifts body composition toward fat loss. Most patients see measurable changes within the first month, with sustained results tracked through quarterly labs.

Energy That Lasts

Improved insulin sensitivity and steadier blood glucose translate to consistent energy throughout the day. No more afternoon crashes or reliance on caffeine to get through.

Metabolic Health Protection

Weight loss at this rate needs monitoring. Your physician tracks 50+ biomarkers including hsCRP, fasting insulin, ApoB, and inflammatory markers to ensure your metabolic health improves alongside your weight.

Physician-Managed Dosing

Your physician adjusts your titration schedule based on your response and labs, not a default calendar. This minimizes side effects while keeping you on the most effective dose.

HSA/FSA Eligible
Modify or cancel anytime
Longevity lab panels
Expert guidance
$179/mo
4.9
|500+ PATIENTS SERVED

Five layers of care
all included from $179/month

Your plan combines physician-prescribed medication, CLIA-certified lab testing, the blēo wearable device, AI coaching, and ongoing physician oversight in one protocol.

GLP-1 Therapy
GLP-1 Therapy

GLP-1 Medication

Physician-prescribed compounded semaglutide or tirzepatide at therapeutic doses.

Licensed US physicians
FDA-regulated medications
100% online
Personalized treatment
Lab tests
Free wearable
Ongoing support
Free shipping
Licensed US physicians
FDA-regulated medications
100% online
Personalized treatment
Lab tests
Free wearable
Ongoing support
Free shipping
Licensed US physicians
FDA-regulated medications
100% online
Personalized treatment
Lab tests
Free wearable
Ongoing support
Free shipping

Your physician is with you every step

Every patient has a US-licensed physician who reviews their lab results, interprets their biomarkers, and calibrates their protocol over time. This is not a one-size-fits-all program.

I've had the same GP tell me my bloods were 'normal' for five years while I felt progressively worse. The difference here is that my physician looked at my numbers with context, not just whether they were in range, but what they meant for me.

Claire B.
Claire B.
51, Chicago

My doc at home is great but doesn't specialize in metabolic health. Having a physician who reviews my quarterly labs specifically for longevity markers changes what the data means. I finally feel like someone's reading the whole picture.

James H.
James H.
49, New York

My physician called me after my first labs came back. Not a nurse, not an assistant. She walked me through every marker and explained what we were going to track over the next quarter. That has never happened to me before.

Natalie R.
Natalie R.
47, Austin

I asked my physician why my dose was lower than what I'd read about online. He pulled up my liver enzymes and walked me through the reasoning. That conversation alone was worth more than any telehealth visit I've had.

Derek S.
Derek S.
55, Denver

After three months my physician adjusted my protocol based on my wearable data and updated labs. She didn't wait for me to ask. That kind of proactive care is why I'm still here.

Karen L.
Karen L.
44, Portland

I brought my results to my GP and he said he'd never seen a panel that thorough from a telehealth provider. Fifty biomarkers, all annotated with context. That's the standard I didn't know I was missing.

Aisha M.
Aisha M.
39, Atlanta

My physician noticed my ApoB was creeping up before my weight had even changed. He flagged it, explained the cardiovascular link, and adjusted my protocol that week. Nobody else was watching that number.

Paul D.
Paul D.
61, Phoenix

I told my physician I was struggling with energy around 2pm every day. She cross-referenced my wearable sleep data with my glucose trends and found the pattern. The fix was a timing change, not a dose change.

Tara J.
Tara J.
43, Nashville

When I hit a plateau at month four, my physician didn't just increase the dose. He ordered updated labs, found my thyroid was slightly off, and addressed that first. The weight started moving again within three weeks.

Marcus W.
Marcus W.
52, Charlotte

I've had the same GP tell me my bloods were 'normal' for five years while I felt progressively worse. The difference here is that my physician looked at my numbers with context, not just whether they were in range, but what they meant for me.

Claire B.
Claire B.
51, Chicago

My doc at home is great but doesn't specialize in metabolic health. Having a physician who reviews my quarterly labs specifically for longevity markers changes what the data means. I finally feel like someone's reading the whole picture.

James H.
James H.
49, New York

My physician called me after my first labs came back. Not a nurse, not an assistant. She walked me through every marker and explained what we were going to track over the next quarter. That has never happened to me before.

Natalie R.
Natalie R.
47, Austin

I asked my physician why my dose was lower than what I'd read about online. He pulled up my liver enzymes and walked me through the reasoning. That conversation alone was worth more than any telehealth visit I've had.

Derek S.
Derek S.
55, Denver

After three months my physician adjusted my protocol based on my wearable data and updated labs. She didn't wait for me to ask. That kind of proactive care is why I'm still here.

Karen L.
Karen L.
44, Portland

I brought my results to my GP and he said he'd never seen a panel that thorough from a telehealth provider. Fifty biomarkers, all annotated with context. That's the standard I didn't know I was missing.

Aisha M.
Aisha M.
39, Atlanta

My physician noticed my ApoB was creeping up before my weight had even changed. He flagged it, explained the cardiovascular link, and adjusted my protocol that week. Nobody else was watching that number.

Paul D.
Paul D.
61, Phoenix

I told my physician I was struggling with energy around 2pm every day. She cross-referenced my wearable sleep data with my glucose trends and found the pattern. The fix was a timing change, not a dose change.

Tara J.
Tara J.
43, Nashville

When I hit a plateau at month four, my physician didn't just increase the dose. He ordered updated labs, found my thyroid was slightly off, and addressed that first. The weight started moving again within three weeks.

Marcus W.
Marcus W.
52, Charlotte

My physician noticed my ApoB was creeping up before my weight had even changed. He flagged it, explained the cardiovascular link, and adjusted my protocol that week. Nobody else was watching that number.

Paul D.
Paul D.
61, Phoenix

I told my physician I was struggling with energy around 2pm every day. She cross-referenced my wearable sleep data with my glucose trends and found the pattern. The fix was a timing change, not a dose change.

Tara J.
Tara J.
43, Nashville

When I hit a plateau at month four, my physician didn't just increase the dose. He ordered updated labs, found my thyroid was slightly off, and addressed that first. The weight started moving again within three weeks.

Marcus W.
Marcus W.
52, Charlotte

I have a family history of heart disease and told my physician on day one. Every quarterly review since has included a cardiovascular risk breakdown alongside the weight data. That context matters to me.

Sandra F.
Sandra F.
56, Minneapolis

My physician reduced my dose after my second quarter because my inflammation markers had improved enough. She said the goal was the lowest effective dose, not the highest tolerable one. That philosophy is rare.

Elena C.
Elena C.
41, Boston

I asked about muscle loss after reading about it online. My physician pulled up my body composition trend from the wearable and showed me lean mass was stable. Data over fear. That is how it should work.

Chris N.
Chris N.
48, San Francisco

I've had the same GP tell me my bloods were 'normal' for five years while I felt progressively worse. The difference here is that my physician looked at my numbers with context, not just whether they were in range, but what they meant for me.

Claire B.
Claire B.
51, Chicago

My doc at home is great but doesn't specialize in metabolic health. Having a physician who reviews my quarterly labs specifically for longevity markers changes what the data means. I finally feel like someone's reading the whole picture.

James H.
James H.
49, New York

My physician called me after my first labs came back. Not a nurse, not an assistant. She walked me through every marker and explained what we were going to track over the next quarter. That has never happened to me before.

Natalie R.
Natalie R.
47, Austin

My physician noticed my ApoB was creeping up before my weight had even changed. He flagged it, explained the cardiovascular link, and adjusted my protocol that week. Nobody else was watching that number.

Paul D.
Paul D.
61, Phoenix

I told my physician I was struggling with energy around 2pm every day. She cross-referenced my wearable sleep data with my glucose trends and found the pattern. The fix was a timing change, not a dose change.

Tara J.
Tara J.
43, Nashville

When I hit a plateau at month four, my physician didn't just increase the dose. He ordered updated labs, found my thyroid was slightly off, and addressed that first. The weight started moving again within three weeks.

Marcus W.
Marcus W.
52, Charlotte

I have a family history of heart disease and told my physician on day one. Every quarterly review since has included a cardiovascular risk breakdown alongside the weight data. That context matters to me.

Sandra F.
Sandra F.
56, Minneapolis

My physician reduced my dose after my second quarter because my inflammation markers had improved enough. She said the goal was the lowest effective dose, not the highest tolerable one. That philosophy is rare.

Elena C.
Elena C.
41, Boston

I asked about muscle loss after reading about it online. My physician pulled up my body composition trend from the wearable and showed me lean mass was stable. Data over fear. That is how it should work.

Chris N.
Chris N.
48, San Francisco

I've had the same GP tell me my bloods were 'normal' for five years while I felt progressively worse. The difference here is that my physician looked at my numbers with context, not just whether they were in range, but what they meant for me.

Claire B.
Claire B.
51, Chicago

My doc at home is great but doesn't specialize in metabolic health. Having a physician who reviews my quarterly labs specifically for longevity markers changes what the data means. I finally feel like someone's reading the whole picture.

James H.
James H.
49, New York

My physician called me after my first labs came back. Not a nurse, not an assistant. She walked me through every marker and explained what we were going to track over the next quarter. That has never happened to me before.

Natalie R.
Natalie R.
47, Austin

Real results. See what patients are saying.

GLP-1 Program

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Woman feeling her best
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Man feeling his best
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Woman feeling energized and confident
Man smiling confidently

More than medication

Access your GLP-1 plan with a comprehensive approach designed for long-term metabolic health.

Comprehensive metabolic wellness — physician, medication, and monitoring
Certified physicians
Complete plan
24/7 access to our Care Team
100% online
Dosage and protocol adjustments, as needed
Continuous longevity monitoring
Personal nutrition and lifestyle coaching

Reviews

5/5
312 Reviews
Andrea V.

Quoted $1,200/mo at a clinic, found this for $179

The weight loss clinic near me wanted $1,200 a month and that was just for the medication. No labs, no wearable, no physician follow-up. I started here at $179 for the first month with everything included. Same class of drug, ten times the support.

Robert K.

Lost 40 lbs twice before, gained it back both times

I have lost and regained 40 pounds twice in my life. This time is different because there is a physician watching my metabolic markers and adjusting the protocol. Five months in, 32 lbs down, and I am not relying on willpower alone to keep it off.

Jasmine T.

My physician titrated at a pace I could handle

I was dreading the nausea everyone talks about online. My physician started me lower than the standard protocol and moved up in small steps over six weeks. I had one queasy morning the entire time. Now I am down 19 lbs and never had to take a sick day.

Frequently askedquestions aboutGLP-1 Therapy

What's your main reason for exploring physician-supervised GLP-1?

Important Safety Information

GLP-1 medications are FDA-approved under certain brand indications. Compounded versions are not FDA-approved.

Prescription products are subject to healthcare provider approval following an online consultation.

Common side effects may include nausea, vomiting, diarrhea, and constipation, particularly during dose escalation.

Do not take GLP-1 therapies if you have a personal or family history of medullary thyroid carcinoma or MEN 2. Seek urgent care for severe abdominal pain or signs of allergic reaction.

Results vary by person and protocol. Compounded medications are not FDA-approved and are prepared by a licensed pharmacy based on a provider's prescription.

Longevity Direct

The GLP-1 program

Physician-supervised protocols with labs, tracking, and ongoing support

LegitScript Certification

© 2026 Longr Holdings Inc.

142 West 57th Street | New York, NY 10019

Prescription products require an online consultation with a physician who will determine if a prescription is appropriate. See product page for important safety information. Benefits outlined on Longevity Direct are based on 3rd party studies.

Medical statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. If you are in need of emergency medical attention, please call 911 immediately.