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Studies have indicated that Rapamycin can increase the lifespan of various organisms, such as yeast, nematodes, fruit flies, and mice. It is believed that rapamycin imitates the benefits of caloric restriction, which has been shown to enhance lifespan in numerous species.
The longevity effects of rapamycin are thought to be a result of its ability to inhibit mTOR, which in turn triggers autophagy, reduces inflammation and cellular senescence, and enhances immune function.
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* Rapamycin is not FDA-approved for the treatment of longevity or anti-aging purposes. Learn more about ‘off-label’ uses.
* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.
* Common side effects of Rapamycin include mouth sores, diarrhea, joint pain, acne, headache, or increased risk of infection. Do not take Rapamycin if you are allergic to it, have liver disease, or have a history of lung or breathing problems.
* Call your doctor immediately if you have symptoms of an allergic reaction such as rash, itching, swelling, severe dizziness, trouble breathing, or symptoms of serious infections.
Rapamycin is a naturally extracted compound found in 1972 on Rapa Nui (Easter Island), which is where it gets its name. It has been used to help the body to accept transplants, to treat lung disease and to treat coronary stents.
It is now being researched as a longevity focused intervention. Since a groundbreaking 2014 experiment showed it could extend the lifespan of mice by 14%, it has been studied for its effect on age related disease and life extension.
The Washington Post, called it a “darling of longevity enthusiasts”, while GQ asked “is the secret to a longer life already available at your local pharmacy?”
To keep himself healthy into his eighth decade, David Sandler recently decided to go beyond his regular workouts and try something experimental: taking rapamycin, an unproven but increasingly popular drug to promote longevity.
In 1972, scientists discovered rapamycin, a compound initially thought to have antifungal properties, in a soil sample from Easter Island. The researchers soon discovered that it had unprecedented anti-cancer activity.
Depending on who you ask, we may be on the cusp of a great leap forward in longevity medicine. “In probably the next three to four years, you will have this pill basket” of anti-aging drugs, says Dr. Vijay Yadav, an assistant professor of genetics and development…
Humans are living longer than ever before, but that doesn’t mean we’re living better. As we age, people have less energy, are more prone to falls and serious injuries, and infections become harder to recover from.
The life of a pet dog follows a predictable trajectory. Over time, the floppy-eared puppy that keeps falling asleep in his food bowl will become a lanky-legged adolescent with an insatiable interest in squirrels — before eventually settling into adulthood as a canine…
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment…
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and healthspan metrics in yeast, invertebrates, and rodents.
Rapamycin is considered a promising anti-aging drug that improves health in old age and alleviates the age-related decline in immune function. A research group at the Max Planck Institute for Biology of Ageing has discovered in fruit flies that rapamycin…
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Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.
Imagine your body as a city, bustling with activity.
Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.
As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.
This is where Rapamycin comes in.
It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on cleanup and repair instead.
Specifically, Rapamycin:
Activates cellular recycling (autophagy):
Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.
Reduces harmful overgrowth:
Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.
Supports stress resilience:
When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.
