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Metformin
Starting at $49
(27 reviews)
A foundational metabolic medication focused on glucose control, steady energy, and long-term healthspan. An effective, daily treatment that mimics the benefits of caloric restriction.
AS FEATURED IN
Personalized Metformin to target the root mechanisms of aging
- Daily tablet protocol
- Clinician-guided longevity plan
- Complete labs & monitoring
- Cancel anytime
Quarterly
most popular
$49/mo.
save 20%
Bi-Annually
recommended protocol
$41.5/mo.
save 33%
Join over 10,000+ people
Metformin
Prescription metformin therapy personalized for your metabolic health and longevity goals.
30+ Longevity Biomarkers
Comprehensive Metabolic Panel (CMP) • Complete Blood Count (CBC)
blēo Wearable
The blēo band combines elegant form with medical-grade sensors.
The Longevity AI
Your all-in-one AI coach to track your progress in real-time.
Transform your longevity journey with Metformin
It takes more than medication alone. Achieving lasting longevity is deeply rewarding but requires commitment. That's why we're dedicated to providing the complete range of science-backed pathways you need to unlock your longevity.
STEP 1Find your solution
Ready to take on time itself? Start by exploring our clinically validated treatments, tailored for your longevity.
Science-Backed
How Metformin works
Metformin operates through multiple biological mechanisms, targeting key pathways involved in metabolic health, cellular energy regulation, and longevity.
Activates AMPK Pathway
Metformin activates AMP-activated protein kinase (AMPK), a master energy sensor in cells. This activation improves insulin sensitivity, increases glucose uptake in muscles, and shifts cellular metabolism toward energy conservation and repair.
Reduces Hepatic Glucose Production
Metformin inhibits gluconeogenesis in the liver, reducing the amount of glucose released into the bloodstream. This mechanism is central to its blood sugar-lowering effects and helps prevent excessive glucose spikes.
Improves Mitochondrial Function
Metformin enhances mitochondrial efficiency and promotes mitochondrial biogenesis. By improving cellular energy production and reducing oxidative stress, it supports healthier aging at the cellular level.
Reduces Inflammation & Oxidative Stress
Metformin decreases inflammatory markers and reduces oxidative damage throughout the body. This anti-inflammatory effect contributes to its protective benefits against age-related diseases and supports overall longevity.
Activates AMPK Pathway
Metformin activates AMP-activated protein kinase (AMPK), a master energy sensor in cells. This activation improves insulin sensitivity, increases glucose uptake in muscles, and shifts cellular metabolism toward energy conservation and repair.
Reduces Hepatic Glucose Production
Metformin inhibits gluconeogenesis in the liver, reducing the amount of glucose released into the bloodstream. This mechanism is central to its blood sugar-lowering effects and helps prevent excessive glucose spikes.
Improves Mitochondrial Function
Metformin enhances mitochondrial efficiency and promotes mitochondrial biogenesis. By improving cellular energy production and reducing oxidative stress, it supports healthier aging at the cellular level.
Reduces Inflammation & Oxidative Stress
Metformin decreases inflammatory markers and reduces oxidative damage throughout the body. This anti-inflammatory effect contributes to its protective benefits against age-related diseases and supports overall longevity.
Testimonials
What our members say
Discover how our members have transformed their health and vitality.
"After just a few months, I feel more energetic and focused than I have in years. The personalized plan is truly making a difference."
"The data-driven approach gave me incredible insights into my health. It's empowering to see my biomarkers improve over time."
"I was skeptical at first, but the results speak for themselves. My sleep has improved, and I've noticed a significant boost in my overall well-being."
"After just a few months, I feel more energetic and focused than I have in years. The personalized plan is truly making a difference."
"The data-driven approach gave me incredible insights into my health. It's empowering to see my biomarkers improve over time."
"I was skeptical at first, but the results speak for themselves. My sleep has improved, and I've noticed a significant boost in my overall well-being."
"The clinical team is top-notch. They explained everything clearly and are always available to answer my questions. I feel like I'm in great hands."
"Integrating the biometric wearable was seamless. It's fascinating to see how my daily habits directly impact my long-term health metrics."
"This program is an investment in my future self. The proactive approach to health is a game-changer."
"The clinical team is top-notch. They explained everything clearly and are always available to answer my questions. I feel like I'm in great hands."
"Integrating the biometric wearable was seamless. It's fascinating to see how my daily habits directly impact my long-term health metrics."
"This program is an investment in my future self. The proactive approach to health is a game-changer."
"My cognitive function has noticeably improved. I feel sharper at work and more present in my daily life."
"The convenience of having everything managed online, from consultations to medication delivery, is incredible."
"Finally, a healthcare company that's focused on optimizing healthspan, not just treating sickness. I highly recommend it."
"My cognitive function has noticeably improved. I feel sharper at work and more present in my daily life."
"The convenience of having everything managed online, from consultations to medication delivery, is incredible."
"Finally, a healthcare company that's focused on optimizing healthspan, not just treating sickness. I highly recommend it."
Research Uncovered
Backed by Science
Explore the clinical research and scientific evidence that validate the benefits for health and longevity.
Mimics Caloric Restriction Benefits
Metformin activates the AMPK pathway, mimicking some of the key cellular benefits of caloric restriction, a well-known longevity intervention.
Harrison et al., Nature, 2009Reduces All-Cause Mortality
Large observational studies show that individuals with diabetes taking metformin have a lower risk of all-cause mortality, suggesting benefits that extend beyond just blood sugar control.
Montero et al., Int Urol Nephrol, 2015The TAME Trial
Metformin is the subject of the landmark TAME (Targeting Aging with Metformin) trial, the first large-scale study designed to prove a drug can delay age-related diseases.
Chaurasiya & Jain, Iran J Sci, 2023Decades of Proven Safety
With over 60 years of widespread clinical use, metformin has a well-established safety profile, making it a trusted choice for long-term therapy.
Montero et al., Int Urol Nephrol, 2015Ready for longevity?
* Metformin is FDA-approved for the treatment of Type 2 Diabetes. Its use for longevity or anti-aging is considered 'off-label'. Learn more about 'off-label' uses.
* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.
* Common side effects of Metformin include diarrhea, nausea, and upset stomach. Long-term use may lead to Vitamin B12 deficiency. Do not take Metformin if you have severe kidney disease, metabolic acidosis, or are allergic to it.
* Call your doctor immediately if you have symptoms of lactic acidosis such as unusual muscle pain, trouble breathing, stomach pain, dizziness, or feeling cold, weak, or tired.
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