Trusted access to clinically validated, US physician prescribed longevity medications and protocols, advanced biomarker testing, and a powerful wearable connected to your own biometric AI longevity coach.
Longevity just got personal. Slow time down, protect vitality.
Plans start at less than $1 per day. No lock in. All 50 states.
Targeted, clinically validated treatments to address the root causes of aging.
Prescribed to keep aging on the defensive, it’s the solid bedrock every effective longevity plan needs.
LONGEVITY DIRECT
A seamless experience, medications delivered straight to your door, online access to experienced US physicians, coaching, testing, optimization, and monitoring – all supported by our unbeatable care.
No waiting rooms, no hidden fees.
All included in your plan.
Science-backed treatments are the cornerstone of any effective longevity program.
Diligently prescribed to suit your needs, your medication targets the underlying mechanisms of aging to help you thrive.
The first longevity wearable to harness the power of biometric AI. Usually $149, included in your plan.
Refining millions of unique longevity signals, it unlocks clear, actionable guidance tailored to your unique longevity profile.
Your all-in-one coach for fitness, nutrition, sleep, and mindfulness.
Powered by data and designed for results, it turns insights into meaningful longevity progress tracking.
For queries related to your medication, our physicians are available to provide clear guidance and support.
They are here to address your concerns and ensure your treatment aligns with your unique health profile.
Online access – anywhere, anytime. Managed securely through your personal online portal.
Physician trusted, clinically tested medications, to meet your unique needs.
Consultations and continuous support from licensed providers, across all 50 states.
US based, certified pharmacies deliver your medication with free, discreet, shipping to your door.
It takes more than medication alone.
Achieving lasting longevity is deeply rewarding but requires commitment.
That’s why we’re dedicated to providing the complete range of science-backed pathways you need to unlock your longevity.
Simple, tailored, results-driven.
Your 5-step journey makes it easy to take control of aging and achieve your best, healthiest self.
Access clinically validated medications redefining how we approach aging.
A groundbreaking 40-month study has revealed that metformin, a widely used diabetes medication, can significantly slow biological aging across multiple tissues.
✅ 6-year reversal in brain aging
✅ Enhanced cognitive abilities and preserved brain structure
✅ Multi-tissue aging slowed through the activation of Nrf2, a powerful antioxidant pathway
This research offers a glimpse into the potential of metformin in combating human aging 🌱
Curious? ⤵️
https://longevity.direct/
📚 Source: Yang et al., Cell, 2024.
#LongevityScience #HealthyAging #Metformin
(Note: Metformin is not currently FDA-approved for anti-aging purposes.)
2025 is the year we redefine health 🌍
Currently, 90% of healthcare spending addresses diseases after they occur, even though many chronic illnesses - causing 70% of deaths - are preventable through proactive measures.
This is the year we commit to prevention.
Science is on our side.
🤝
Are you ready? ⤵️
https://longevity.direct/
#PreventiveHealth #HealthyAging #Longevity
Your lunch can now tell you more about your future than a fortune cookie ever could...
With The Longevity AI (included in your Longevity Direct plan), your personal nutritionist works 24/7 to help you:
🔍 See what’s really on your plate – calories, macros, and longevity benefits.
🥗 Make better food choices – guided by real data, not guesswork.
🧬 Turn your meals into momentum – plan today to shape how you feel tomorrow.
It’s helping you eat for the years you haven’t lived yet.
Ready to take the first bite? ⤵️
https://longevity.direct/
#HealthyEating #LongevityLifestyle #FoodTech
A decades-old diabetes drug could hold the secret to longevity?
Metformin, trusted by millions since the 1950s, has spent decades proving its worth in managing type 2 diabetes.
Now, it’s stepping boldly into the anti-aging spotlight.
Insights from Frontiers in Endocrinology and other leading studies highlight its exciting possibilities for longevity science:
🔹 A Proven Track Record: Safely prescribed for over 60 years, metformin helps control blood sugar while improving cardiovascular health and reducing risks of complications like cancer.
🔹 Cellular Repair & Longevity: Activates AMPK and autophagy, promoting cellular recycling and reducing inflammation - two hallmarks of longevity.
🔹 Cognitive Function & Brain Health: May protect against cognitive decline by improving blood flow and reducing oxidative stress in the brain.
🔹 Skin & Bone Aging: Supports facial bone density and reduces skin aging markers - longevity you can feel and see.
With groundbreaking trials like TAME leading the way, the evidence is growing that it could redefine how we age.
Will metformin play a part in your future? ⤵️
https://longevity.direct
#Metformin #LongevityScience #Healthspan
(Note: Metformin is not currently FDA-approved for anti-aging purposes.)
Targeting aging at its source - sounds futuristic, right?
Rapamycin is known as the darling of longevity science for a reason.
It modulates the mTOR pathway, your body’s cellular control center, shifting it into repair mode.
The studied results?..
Better cellular renewal, reduced inflammation, and potential protection against age-related diseases like cardiovascular decline, neurodegeneration, and even certain cancers.
Curious about Rapamycin for your longevity? ⤵️
https://longevity.direct/
#LongevityMedicine #Rapamycin #HealthyAging
(Please note: Rapamycin is not FDA-approved for anti-aging purposes)
Longevity Direct is an element within Longr’s Longevity OS, a platform dedicated to extending access to longevity.
© 2025 Longr Holdings Inc.
If you’re looking to age better – whether by optimizing your health or addressing early signs of decline – Rapamycin could be a meaningful step forward.
By targeting the mTOR pathway, Rapamycin helps shift your body’s focus from growth to repair, promoting cellular health and reducing inflammation.
Research suggests it may improve immune function, support cognitive health, and lower risks of age-related diseases like cardiovascular decline and cancer.
While Rapamycin is prescribed “off-label” for longevity purposes, it’s backed by extensive studies and careful medical oversight ensures it’s safe and effective.
At Longevity Direct, we tailor your treatment plan through a detailed intake process, supported blēo and The Longevity AI to track your progress.
Once approved, your plan evolves to meet your needs.
Safety
Rapamycin is administered in low, intermittent doses to minimize risks.
Any potential side effects, such as mild digestive upset or temporary immune changes, are rare and manageable with proper care.
Our team ensures you’re supported every step of the way.
Important to know
Rapamycin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Rapamycin is one of the most studied compounds in longevity science, attracting significant interest from researchers worldwide.
With decades of research across organisms from yeast to mammals, it has consistently demonstrated its potential to extend lifespan and improve healthspan.
Proven to extend lifespan:
Rapamycin has extended lifespan in every organism tested, from yeast to mammals, by targeting the mTOR pathway.
(Source: EUROPE PMC)
Improves healthspan:
Rapamycin slows age-related decline, supporting healthier cells and delaying aging-associated conditions.
(Source: EUROPE PMC)
Boosts immune function:
Enhances immune response, particularly in older adults, by promoting cellular repair and reducing inflammation.
Reduces risks of specific conditions:
Cognitive protection:
May slow cognitive decline by reducing neuroinflammation and supporting brain health.
(Source: OXFORD ACADEMIC)
Metabolic health:
Improves insulin sensitivity and reduces systemic inflammation linked to metabolic disorders.
(Source: PLOS JOURNALS)
Organ health:
Protects organs like the kidneys and liver from age-related damage via cellular repair mechanisms.
(Source: PLOS JOURNALS)
Cancer risk reduction:
Slows the progression of certain cancers by inhibiting cell proliferation and activating autophagy.
(Source: PLOS JOURNALS)
Joint and bone health:
Research suggests it may alleviate arthritis symptoms and improve bone density.
(Source: PLOS JOURNALS)
Important to know
Rapamycin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.
Imagine your body as a city, bustling with activity.
Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.
As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.
This is where Rapamycin comes in.
It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.
Specifically, Rapamycin:
Activates cellular recycling (autophagy):
Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.
Reduces harmful overgrowth:
Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.
Supports stress resilience:
When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.
Temporary immune changes:
Rapamycin can cause mild immunosuppression, making it essential to follow dosing guidelines closely.
Digestive issues:
Some users report mild nausea, diarrhea, or stomach discomfort.
Mouth sores:
A common but manageable side effect, especially at higher doses.
Fatigue or headaches:
Occasionally experienced but typically mild.
With proper medical oversight and careful dosing, these risks are both manageable and avoidable.
At Longevity Direct, our team closely monitors your progress to ensure the safest, most effective treatment plan for your needs.
Important to know
Rapamycin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
If you’re looking to improve your metabolic health or address early signs of aging, Metformin may be a valuable tool in your longevity plan.
Metformin is particularly beneficial for individuals with: a desire to reduce age-related risks such as metabolic disorders or cardiovascular decline; for a proactive approach to managing weight and glucose levels.
While it’s prescribed off-label for longevity purposes, decades of clinical use have demonstrated its safety and potential benefits beyond glucose control.
At Longevity Direct, we tailor your treatment plan through a detailed intake process, supported blēo and The Longevity AI to track your progress.
Once approved, your plan evolves to meet your needs.
Safety
Metformin is generally well-tolerated, especially when started at a low dose. Common side effects, like mild stomach upset, are manageable and often subside as your body adjusts.
Important to know
Metformin is not FDA-approved for longevity or anti-aging purposes. All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile.
Metformin has become a cornerstone of longevity research, with evidence supporting its ability to improve healthspan and metabolic function.
Activates longevity pathways:
Metformin enhances AMPK, a key pathway linked to longer life and improved metabolic efficiency.
Improves metabolic health:
Reduces inflammation and insulin resistance, protecting against age-related metabolic disorders.
Supports cardiovascular health:
Lowers the risk of heart disease by improving lipid profiles and reducing systemic inflammation.
Protects brain function:
Research suggests it may lower risks of cognitive decline and dementia by reducing neuroinflammation and enhancing energy use in the brain.
Promotes weight management:
Helps reduce body weight by improving glucose regulation and supporting fat metabolism.
Reduces risks of certain cancers:
Studies indicate that Metformin may inhibit the growth of some cancers by lowering insulin levels and reducing oxidative stress.
Important to know
Metformin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Metformin works by optimizing how your body processes and uses energy, focusing on metabolic stability and cellular efficiency.
Think of your body as a power grid.
Every cell needs energy, and your liver acts as the central generator, controlling how much fuel (glucose) is produced and distributed.
With age, this system can become inefficient, producing excess glucose and overloading your cells.
Metformin steps in like an expert energy manager.
It tells your liver to slow down glucose production and helps your muscles and cells better absorb the fuel they need – no more, no less.
Specifically, Metformin:
Activates AMPK, the energy regulator:
AMPK acts like a circuit breaker, ensuring energy is used efficiently. By turning it on, Metformin enhances mitochondrial function and reduces wasteful processes.
Reduces insulin resistance:
Metformin helps your cells respond better to insulin, preventing spikes in blood sugar that can lead to inflammation and aging-related damage.
Promotes cellular repair:
By improving nutrient sensing, Metformin supports autophagy (the body’s cleanup process) to remove damaged components and rejuvenate cells.
Metformin is widely recognized as safe, but like any medication, it may cause side effects. These are generally mild and manageable.
Digestive issues:
Some patients experience nausea, diarrhea, or stomach discomfort, especially when starting treatment. Gradual dose increases and taking the medication with food can help.
Vitamin B12 deficiency:
Long-term use may lower B12 levels, potentially leading to fatigue or nerve issues. Regular monitoring and supplementation can address this.
Rare but serious risks:
In very rare cases, Metformin can cause lactic acidosis, characterized by symptoms like severe tiredness or shallow breathing. This is extremely uncommon but requires immediate medical attention.
With proper medical oversight and careful dosing, these risks are both manageable and avoidable.
At Longevity Direct, our team closely monitors your progress to ensure the safest, most effective treatment plan for your needs.
Important to know
Metformin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.