Your Longevity Clinic,
from Home.

Preventing age-related disease starts here.

Trusted access to clinically validated, US physician prescribed longevity medications and protocols, advanced biomarker testing, and a powerful wearable connected to your own biometric AI longevity coach.

We analyze over 28,000,000 unique data points for one outcome, your longevity.

Plans from less than $1 per day. No lock in.

Validated medications
for health and longevity

Targeted, clinically validated treatments to address the root causes of aging.

Prescribed to keep aging on the defensive, it’s the solid bedrock every effective longevity plan needs.

LONGEVITY DIRECT

Clinic experience from your home

A seamless experience, medications delivered straight to your door, online access to experienced US physicians, coaching, testing, optimization, and monitoring – all supported by our unbeatable care.

No waiting rooms, no hidden fees.

All included in your plan.

Medication

Science-backed treatments are the cornerstone of any effective longevity program.

Diligently prescribed to suit your needs, your medication targets the underlying mechanisms of aging to help you thrive.

The first longevity wearable to harness the power of biometric AI. Usually $149, included in your plan. 

Refining millions of unique longevity signals, it unlocks clear, actionable guidance tailored to your unique longevity profile.

Your all-in-one coach for fitness, nutrition, sleep, and mindfulness.

Powered by data and designed for results, it turns insights into meaningful longevity progress tracking. 

Lab Tests

Understanding your body’s inner workings is the cornerstone of effective longevity planning.
 

All plans include comprehensive and frequent lab testing, which may include CBC, CMP, Lipid Panel, hs-CRP, and Hemoglobin A1c.

Physician On Demand

For queries related to your medication, our physicians are available to provide clear guidance and support.

They are here to address your concerns and ensure your treatment aligns with your unique health profile.

It's all about you

We collect and analyze over 28,000,000 unique data points for one outcome, your longevity.

Your habits, reimagined for longevity.

Analyzing millions of behavioral data points, from fitness routines to mindfulness practices, optimize your everyday habits for a masterclass in living longer.

This is more than coaching, it’s precision-engineered progress.

Millions of signals, 70+ biometrics, one goal.

With 70+ biometric data points, from heart rate variability to sleep cycles and stress levels, and millions of reads each year, blēo empowers you to understand and optimize your longevity every second of the day.

It’s not just tracking, it’s transforming how we approach your longevity.

Forget guesswork.

Our comprehensive lab tests dive deep into 50+ biomarkers and thousands of longitudinal data points under the hood, tracking everything from inflammation to metabolic precision.

The precision and clarity needed to shape your strategy.

Your DNA isn’t a blueprint, it’s a toolkit.

By analyzing hundreds of thousands of CpG sites, we uncover the pathways to lower your biological age, turbocharge your immune system, and tackle inflammation head-on.

This isn’t just knowledge; it’s the key to unlocking the healthiest version of you.

Preventing age-related disease starts here

It takes more than medication alone.

Achieving lasting longevity is deeply rewarding but requires commitment.

That’s why we’re dedicated to providing the complete range of science-backed pathways you need to unlock your longevity.

General Longevity
Live well, longer
Heart Health
Strengthen every beat
Glucose Control
Balance from within
Cognitive Function
Sharpen your mind
Blood Pressure
Stay steady, stay strong
Autoimmune support
Empower your resilience

Private care,
100% online

Online access – anywhere, anytime. Managed securely through your personal online portal.

Clinically validated
medications

Physician trusted, clinically tested medications, to meet your unique needs.

Prescribed by
licensed providers

Consultations and continuous support from licensed providers, across all 50 states.

From US Pharmacies
to your door

US based, certified pharmacies deliver your medication with free, discreet, shipping to your door.

Your path to longevity

Simple, tailored, results-driven.

Your 5-step journey makes it easy to take control of aging and achieve your best, healthiest self.

Research

Access clinically validated medications redefining how we approach aging.

How does Rapamycin work?
Potential
side effects
How does Metformin work?
Potential
side effects
What are GLP-1 receptor agonists (Semaglutide and Tirzepatide)?
Studied benefits
of GLP-1s (Semaglutide and Tirzepatide)?
How do Semaglutide and Tirzepatide work?
Potential
side effects
Your body is dropping longevity hints - are you picking them up? 🤔

A 3% fall in VO2 max, lower HRV, and declining sleep efficiency all point to one thing: your body is under stress. 

These markers are vital indicators of cardiovascular fitness, recovery, and resilience - crucial for long-term health.

The Longevity AI doesn’t do vague warnings - it does solutions. Track, analyze, adjust. 

What’s your body telling you? And more importantly, what are you going to do about it? ⤵️

https://longevity.direct/

#Longevity #HealthOptimization #VO2max
A metabolism reset, no injections required...

Tirzepatide, the active ingredient in Mounjaro®, is reshaping healthy aging. 

Like semaglutide, it helps regulate blood sugar, curb appetite, and support weight loss - but research suggests some may experience fewer side effects like nausea and GI discomfort. 

And now?..

It’s available in an easy-to-take oral form.

The bigger picture?.. 

Improved insulin sensitivity, reduced inflammation, and a lower risk of metabolic diseases like diabetes and cardiovascular decline. 

Curious about Tirzepatide tablets for your longevity? ⤵️

https://longevity.direct/

#LongevityLifestyle #Semaglutide #Tirzepatide

(Please note: Tirzepatide is not FDA-approved for anti-aging purposes)
Imagine your heart as a finely tuned orchestra, each beat a note in the grand symphony of your health.

Heart Rate Variability (HRV), the variation in time between those beats, might just be the conductor, hinting at how well your body is adapting to stress, recovery, and ultimately, aging.

Here’s the big picture:

📈 A higher HRV? Think resilience, vitality, and an orchestra in perfect harmony.

📉 A lower HRV? That’s the system struggling to keep tempo—often linked to stress, poor sleep, and declining health.

You can influence your HRV. We do it at Longevity Direct.

Small, deliberate changes, like prioritizing rest, reducing stress, and optimizing your nutrition, can help you take back control of your biological rhythm.

Your body is always speaking - listen and act.

#HeartHealth #HRV #HealthyAging
Yes, you read that right 🤯

A study of over 1 million patients (!) revealed that Semaglutide slashed the risk of first-time Alzheimer’s diagnosis by 40-70%. 

Semaglutide might be proof that prevention — real, scalable, impactful prevention — isn’t just possible but achievable.

⤵️

https://longevity.direct/

📚 Source: Wang et al., Alzheimer's & Dementia (2024), Wiley. DOI: 10.1002/alz.14313

#Ozempic #Semaglutide #Alzheimers #Longevity #Breakthrough
A groundbreaking 40-month study has revealed that metformin, a widely used diabetes medication, can significantly slow biological aging across multiple tissues. 

✅ 6-year reversal in brain aging

✅ Enhanced cognitive abilities and preserved brain structure

✅ Multi-tissue aging slowed through the activation of Nrf2, a powerful antioxidant pathway

This research offers a glimpse into the potential of metformin in combating human aging 🌱

Curious? ⤵️

https://longevity.direct/

📚 Source: Yang et al., Cell, 2024.

#LongevityScience #HealthyAging #Metformin

(Note: Metformin is not currently FDA-approved for anti-aging purposes.)
2025 is the year we redefine health 🌍

Currently, 90% of healthcare spending addresses diseases after they occur, even though many chronic illnesses - causing 70% of deaths - are preventable through proactive measures.

This is the year we commit to prevention. 

Science is on our side.

🤝

Are you ready? ⤵️

https://longevity.direct/

#PreventiveHealth #HealthyAging #Longevity
Your lunch can now tell you more about your future than a fortune cookie ever could...

With The Longevity AI (included in your Longevity Direct plan), your personal nutritionist works 24/7 to help you:

🔍 See what’s really on your plate – calories, macros, and longevity benefits.

🥗 Make better food choices – guided by real data, not guesswork.

🧬 Turn your meals into momentum – plan today to shape how you feel tomorrow.

It’s helping you eat for the years you haven’t lived yet. 

Ready to take the first bite? ⤵️

https://longevity.direct/

#HealthyEating #LongevityLifestyle #FoodTech

Is Rapamycin right for me?

If you’re looking to age better – whether by optimizing your health or addressing early signs of decline – Rapamycin could be a meaningful step forward.

By targeting the mTOR pathway, Rapamycin helps shift your body’s focus from growth to repair, promoting cellular health and reducing inflammation.

Research suggests it may improve immune function, support cognitive health, and lower risks of age-related diseases like cardiovascular decline and cancer.

While Rapamycin is prescribed “off-label” for longevity purposes, it’s backed by extensive studies and careful medical oversight ensures it’s safe and effective.

At Longevity Direct, we tailor your treatment plan through a detailed intake process, supported blēo and The Longevity AI to track your progress.

Once approved, your plan evolves to meet your needs.

Safety

Rapamycin is administered in low, intermittent doses to minimize risks.

Any potential side effects, such as mild digestive upset or temporary immune changes, are rare and manageable with proper care.

Our team ensures you’re supported every step of the way.

Important to know

Rapamycin is not FDA-approved for longevity or anti-aging purposes.

Prescriptions are approved through an online consultation with a licensed healthcare provider.

What are the studied benefits of Rapamycin?

Rapamycin is one of the most studied compounds in longevity science, attracting significant interest from researchers worldwide.

With decades of research across organisms from yeast to mammals, it has consistently demonstrated its potential to extend lifespan and improve healthspan. 

Proven to extend lifespan: 

Rapamycin has extended lifespan in every organism tested, from yeast to mammals, by targeting the mTOR pathway. 
(Source: EUROPE PMC)

Improves healthspan: 

Rapamycin slows age-related decline, supporting healthier cells and delaying aging-associated conditions.
(Source: EUROPE PMC)

Boosts immune function: 

Enhances immune response, particularly in older adults, by promoting cellular repair and reducing inflammation.

Reduces risks of specific conditions:

Cognitive protection: 
May slow cognitive decline by reducing neuroinflammation and supporting brain health. 
(Source: OXFORD ACADEMIC)

Metabolic health: 
Improves insulin sensitivity and reduces systemic inflammation linked to metabolic disorders. 
(Source: PLOS JOURNALS)

Organ health: 
Protects organs like the kidneys and liver from age-related damage via cellular repair mechanisms. 
(Source: PLOS JOURNALS)

Cancer risk reduction: 
Slows the progression of certain cancers by inhibiting cell proliferation and activating autophagy. 
(Source: PLOS JOURNALS)

Joint and bone health: 
Research suggests it may alleviate arthritis symptoms and improve bone density. 
(Source: PLOS JOURNALS)

Important to know

Rapamycin is not FDA-approved for longevity or anti-aging purposes.

Prescriptions are approved through an online consultation with a licensed healthcare provider.

How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.

What are the potential side effects of Rapamycin?

Temporary immune changes: 
Rapamycin can cause mild immunosuppression, making it essential to follow dosing guidelines closely.

Digestive issues: 
Some users report mild nausea, diarrhea, or stomach discomfort.

Mouth sores: 
A common but manageable side effect, especially at higher doses.

Fatigue or headaches: 
Occasionally experienced but typically mild.

With proper medical oversight and careful dosing, these risks are both manageable and avoidable. 

At Longevity Direct, our team closely monitors your progress to ensure the safest, most effective treatment plan for your needs.

Important to know

Rapamycin is not FDA-approved for longevity or anti-aging purposes.

Prescriptions are approved through an online consultation with a licensed healthcare provider.

Is Metformin right for me?

If you’re looking to improve your metabolic health or address early signs of aging, Metformin may be a valuable tool in your longevity plan.

Metformin is particularly beneficial for individuals with: a desire to reduce age-related risks such as metabolic disorders or cardiovascular decline; for a proactive approach to managing weight and glucose levels.

While it’s prescribed off-label for longevity purposes, decades of clinical use have demonstrated its safety and potential benefits beyond glucose control.

At Longevity Direct, we tailor your treatment plan through a detailed intake process, supported blēo and The Longevity AI to track your progress.

Once approved, your plan evolves to meet your needs.

Safety

Metformin is generally well-tolerated, especially when started at a low dose. Common side effects, like mild stomach upset, are manageable and often subside as your body adjusts.

Important to know

Metformin is not FDA-approved for longevity or anti-aging purposes. All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile.

What are the studied benefits of Metformin?

Metformin has become a cornerstone of longevity research, with evidence supporting its ability to improve healthspan and metabolic function.

Activates longevity pathways:
Metformin enhances AMPK, a key pathway linked to longer life and improved metabolic efficiency.

Improves metabolic health:
Reduces inflammation and insulin resistance, protecting against age-related metabolic disorders.

Supports cardiovascular health:
Lowers the risk of heart disease by improving lipid profiles and reducing systemic inflammation.

Protects brain function:
Research suggests it may lower risks of cognitive decline and dementia by reducing neuroinflammation and enhancing energy use in the brain.

Promotes weight management:
Helps reduce body weight by improving glucose regulation and supporting fat metabolism.

Reduces risks of certain cancers:
Studies indicate that Metformin may inhibit the growth of some cancers by lowering insulin levels and reducing oxidative stress.

Important to know

Metformin is not FDA-approved for longevity or anti-aging purposes.

Prescriptions are approved through an online consultation with a licensed healthcare provider.

How does Metformin work?

Metformin works by optimizing how your body processes and uses energy, focusing on metabolic stability and cellular efficiency.

Think of your body as a power grid.

Every cell needs energy, and your liver acts as the central generator, controlling how much fuel (glucose) is produced and distributed.

With age, this system can become inefficient, producing excess glucose and overloading your cells.

Metformin steps in like an expert energy manager.

It tells your liver to slow down glucose production and helps your muscles and cells better absorb the fuel they need – no more, no less.

Specifically, Metformin:

Activates AMPK, the energy regulator:
AMPK acts like a circuit breaker, ensuring energy is used efficiently. By turning it on, Metformin enhances mitochondrial function and reduces wasteful processes.

Reduces insulin resistance:
Metformin helps your cells respond better to insulin, preventing spikes in blood sugar that can lead to inflammation and aging-related damage.

Promotes cellular repair:
By improving nutrient sensing, Metformin supports autophagy (the body’s cleanup process) to remove damaged components and rejuvenate cells.

What are the potential side effects of Metformin?

Metformin is widely recognized as safe, but like any medication, it may cause side effects. These are generally mild and manageable.

Digestive issues:
Some patients experience nausea, diarrhea, or stomach discomfort, especially when starting treatment. Gradual dose increases and taking the medication with food can help.

Vitamin B12 deficiency:
Long-term use may lower B12 levels, potentially leading to fatigue or nerve issues. Regular monitoring and supplementation can address this.

Rare but serious risks:
In very rare cases, Metformin can cause lactic acidosis, characterized by symptoms like severe tiredness or shallow breathing. This is extremely uncommon but requires immediate medical attention.

With proper medical oversight and careful dosing, these risks are both manageable and avoidable. 

At Longevity Direct, our team closely monitors your progress to ensure the safest, most effective treatment plan for your needs.

Important to know

Metformin is not FDA-approved for longevity or anti-aging purposes.

Prescriptions are approved through an online consultation with a licensed healthcare provider.

What are GLP-1 receptor agonists (Semaglutide and Tirzepatide)?

GLP-1 receptor agonists, such as Semaglutide (the active ingredient in Wegovy® and Ozempic®) and Tirzepatide (the active ingredient in Mounjaro®), are medications that mimic a natural hormone in your body called glucagon-like peptide-1 (GLP-1)

Originally developed for managing type 2 diabetes, these medications are now recognized for their transformative effects on weight management, metabolic health, and even cognitive function.

Think of GLP-1 as a messenger in your body that ensures everything runs smoothly after meals — like a project manager who keeps energy levels balanced and prevents overindulgence.

GLP-1 receptor agonists amplify this effect, improving your body’s natural ability to regulate blood sugar, control appetite, and burn energy efficiently.

Semaglutide focuses on the GLP-1 pathway, while Tirzepatide is a dual-action therapy that combines GLP-1 with GIP (glucose-dependent insulinotropic polypeptide), like hiring a co-manager to boost productivity even further.

Safety

GLP-1 receptor agonists are generally well-tolerated, particularly when introduced gradually. Common side effects, such as mild nausea or digestive discomfort, are typically temporary and improve as your body adjusts.

Physician oversight ensures that any potential side effects are monitored and managed effectively.

Important to know

GLP-1 receptor agonists are FDA-approved for managing type 2 diabetes and chronic weight management but are not specifically approved for longevity purposes.

All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile and goals.

What are the benefits of Semaglutide and Tirzepatide for Health?

GLP-1 medications are gaining an incredible amount recognition, not just managing conditions like obesity and diabetes, but also enhancing overall health and longevity.

Sustainable weight loss:
These medications consistently support significant and sustained weight loss, which reduces risks for many chronic diseases.

Improved metabolic health:
GLP-1s enhance insulin sensitivity, lower blood sugar levels, and reduce inflammation, combating conditions like type 2 diabetes and metabolic syndrome.

Cardiovascular protection:
Studies have shown reduced heart disease risk, including lower blood pressure and improved cholesterol profiles​

Cognitive support:
Preliminary research suggests benefits for brain health, such as reduced neuroinflammation and potential protection against cognitive decline – including Dementia and Alzheimer’s. 

Important to know

GLP-1 receptor agonists are FDA-approved for managing type 2 diabetes and chronic weight management but are not specifically approved for longevity purposes.

All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile and goals.

How do Semaglutide and Tirzepatide work?

GLP-1 medications, such as Semaglutide (in Wegovy® and Ozempic®) and Tirzepatide (in Mounjaro®), enhance your body’s natural hormonal response to food, helping regulate processes like hunger, digestion, and blood sugar levels.

Imagine your metabolism as a symphony orchestra.

Without a conductor, the players might lose rhythm — leading to chaotic blood sugar spikes, uncontrolled cravings, and inefficient energy use.

GLP-1 acts as the conductor, ensuring every instrument works together in harmony.

Here’s how GLP-1 medications orchestrate balance and health:

Reduce appetite:
GLP-1 interacts with brain centers like the hypothalamus, which regulate hunger and satiety. It signals that you’re full after eating, helping you avoid overeating.

Think of it as flipping the “I’m satisfied” switch sooner, so you feel full with smaller portions.

Slow digestion:
These medications delay how quickly food leaves your stomach, preventing sudden blood sugar spikes and providing a steady release of energy.

It’s like putting your digestive system into “slow release” mode, ensuring a smoother flow of energy instead of a quick sugar rush.

Enhance insulin sensitivity:
GLP-1 improves your body’s response to insulin, the hormone that helps move glucose from your bloodstream into cells for energy. This reduces overall blood sugar levels and inflammation.

Imagine teaching your body to respond better to its insulin, like upgrading from an outdated operating system to a smarter, faster one.

Promote weight loss:
By curbing cravings, reducing caloric intake, and optimizing how your body uses stored fat, GLP-1 medications support sustainable and meaningful weight loss.

It’s like having a coach reminding you to use your energy reserves wisely rather than constantly restocking them.

Reduce inflammation:
Research shows GLP-1 medications may also reduce inflammation in the brain and other tissues, providing potential cognitive and systemic health benefits.

Think of it as a gentle anti-inflammatory mist calming overactive signals throughout your body.

Tirzepatide’s dual-action advantage:
Tirzepatide adds another layer of effectiveness by also targeting GIP, a hormone that works alongside GLP-1 to improve insulin secretion and fat metabolism. This dual approach amplifies benefits like appetite suppression and blood sugar control.

It’s like having two expert conductors leading the same symphony for maximum effect.

What are the potential side effects of Semaglutide and Tirzepatide?

While GLP-1s are generally well-tolerated, they can have side effects. The most common include:

Nausea or vomiting: Especially early in treatment as your body adjusts.

Digestive discomfort: Slower digestion can sometimes cause bloating or constipation.

Injection site reactions (if injectable): These are typically mild and temporary.

Rare but more serious risks include gallbladder issues (e.g., gallstones) and pancreatitis. Careful monitoring ensures these risks remain minimal​.

With proper medical oversight and careful dosing, these risks are both manageable and avoidable. 

At Longevity Direct, we guide you through treatment, addressing any concerns and ensuring you achieve the maximum benefits safely​.

Important to know

GLP-1 receptor agonists are FDA-approved for managing type 2 diabetes and chronic weight management but are not specifically approved for longevity purposes.

All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile and goals.

Contact

Questions, suggestions, reflections?

Fill out the form below and a member of our team well get back to you as soon as possible.

Contact Form (#14)