Explore one of the most trusted and extensively researched longevity therapies, supported by a protocol that prioritizes proven results and expert care.
Starting at $30 / month.
The Longevity Elixir
Metformin has been widely studied for its ability to enhance lifespan and reduce age-related decline.
Its role in activating key longevity pathways makes it a cornerstone in modern longevity science.
Metformin does more than manage glucose levels – it helps optimize your metabolism.
By reducing inflammation, enhancing nutrient sensing, and supporting cellular repair, it sets the foundation for healthier aging and energetic living.
May activate longevity pathways – like those in super-agers.
May enhance mitochondrial function and nutrient sensing.
May reduce cell senescence, inflammation, and risks of diabetes, kidney disease, and certain cancers.
May support brain health, lowering the risk of cognitive decline and dementia.
May improve metabolic health, aiding glucose control and supporting 5-7% weight loss.
LONGEVITY DIRECT
A seamless experience, medications delivered straight to your door, online access to experienced US physicians, coaching, testing, optimization, and monitoring – all supported by our unbeatable care.
No waiting rooms, no hidden fees.
All included in your plan.
Science-backed treatments are the cornerstone of any effective longevity program.
Diligently prescribed to suit your needs, your medication targets the underlying mechanisms of aging to help you thrive.
The first longevity wearable to harness the power of biometric AI. Usually $149, included in your plan.
Refining millions of unique longevity signals, it unlocks clear, actionable guidance tailored to your unique longevity profile.
Your all-in-one coach for fitness, nutrition, sleep, and mindfulness.
Powered by data and designed for results, it turns insights into meaningful longevity progress tracking.
For queries related to your medication, our physicians are available to provide clear guidance and support.
They are here to address your concerns and ensure your treatment aligns with your unique health profile.
* Metformin not FDA-approved for the treatment of longevity or anti-aging purposes. Learn more about ‘off-label’ uses.
* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.
* Common side effects of Metformin include nausea, diarrhea, stomach pain, bloating, gas, indigestion, or a metallic taste in the mouth. Do not take Metformin if you are allergic to it, have severe kidney disease, metabolic acidosis, or diabetic ketoacidosis.
* Call your doctor immediately if you have symptoms of lactic acidosis such as muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Access clinically validated medications redefining how we approach aging.
Longevity Direct is an element within Longr’s Longevity OS, a platform dedicated to extending access to longevity.
© 2025 Longr Holdings Inc.
If you’re looking to improve your metabolic health or address early signs of aging, Metformin may be a valuable tool in your longevity plan.
Metformin is particularly beneficial for individuals with: a desire to reduce age-related risks such as metabolic disorders or cardiovascular decline; for a proactive approach to managing weight and glucose levels.
While it’s prescribed off-label for longevity purposes, decades of clinical use have demonstrated its safety and potential benefits beyond glucose control.
At Longevity Direct, we tailor your treatment plan through a detailed intake process, supported blēo and The Longevity AI to track your progress.
Once approved, your plan evolves to meet your needs.
Safety
Metformin is generally well-tolerated, especially when started at a low dose. Common side effects, like mild stomach upset, are manageable and often subside as your body adjusts.
Important to know
Metformin is not FDA-approved for longevity or anti-aging purposes. All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile.
Metformin has become a cornerstone of longevity research, with evidence supporting its ability to improve healthspan and metabolic function.
Activates longevity pathways:
Metformin enhances AMPK, a key pathway linked to longer life and improved metabolic efficiency.
Improves metabolic health:
Reduces inflammation and insulin resistance, protecting against age-related metabolic disorders.
Supports cardiovascular health:
Lowers the risk of heart disease by improving lipid profiles and reducing systemic inflammation.
Protects brain function:
Research suggests it may lower risks of cognitive decline and dementia by reducing neuroinflammation and enhancing energy use in the brain.
Promotes weight management:
Helps reduce body weight by improving glucose regulation and supporting fat metabolism.
Reduces risks of certain cancers:
Studies indicate that Metformin may inhibit the growth of some cancers by lowering insulin levels and reducing oxidative stress.
Important to know
Metformin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Metformin works by optimizing how your body processes and uses energy, focusing on metabolic stability and cellular efficiency.
Think of your body as a power grid.
Every cell needs energy, and your liver acts as the central generator, controlling how much fuel (glucose) is produced and distributed.
With age, this system can become inefficient, producing excess glucose and overloading your cells.
Metformin steps in like an expert energy manager.
It tells your liver to slow down glucose production and helps your muscles and cells better absorb the fuel they need – no more, no less.
Specifically, Metformin:
Activates AMPK, the energy regulator:
AMPK acts like a circuit breaker, ensuring energy is used efficiently. By turning it on, Metformin enhances mitochondrial function and reduces wasteful processes.
Reduces insulin resistance:
Metformin helps your cells respond better to insulin, preventing spikes in blood sugar that can lead to inflammation and aging-related damage.
Promotes cellular repair:
By improving nutrient sensing, Metformin supports autophagy (the body’s cleanup process) to remove damaged components and rejuvenate cells.
Metformin is widely recognized as safe, but like any medication, it may cause side effects. These are generally mild and manageable.
Digestive issues:
Some patients experience nausea, diarrhea, or stomach discomfort, especially when starting treatment. Gradual dose increases and taking the medication with food can help.
Vitamin B12 deficiency:
Long-term use may lower B12 levels, potentially leading to fatigue or nerve issues. Regular monitoring and supplementation can address this.
Rare but serious risks:
In very rare cases, Metformin can cause lactic acidosis, characterized by symptoms like severe tiredness or shallow breathing. This is extremely uncommon but requires immediate medical attention.
With proper medical oversight and careful dosing, these risks are both manageable and avoidable.
At Longevity Direct, our team closely monitors your progress to ensure the safest, most effective treatment plan for your needs.
Important to know
Metformin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.
Imagine your body as a city, bustling with activity.
Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.
As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.
This is where Rapamycin comes in.
It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.
Specifically, Rapamycin:
Activates cellular recycling (autophagy):
Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.
Reduces harmful overgrowth:
Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.
Supports stress resilience:
When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.