Discover one of the most advanced longevity therapies available today, with a protocol and support that goes beyond just a prescription.
Starting at $75.
The Darling of Longevity Enthusiasts
Rapamycin has been proven to extend the lifespan of every organism studied, from yeast to mammals.
Its ability to target the biological mechanisms of aging makes it one of the most promising developments in longevity science.
Rapamycin has been shown to improve not just how long you live but how well you live.
It has been shown to promote cellular repair and reducing age-related decline, it supports healthier aging and a higher quality of life.
May target the root causes of aging by modulating the mTOR pathway – a key regulator of cellular repair and growth.
May promote cellular renewal through autophagy, the body’s natural recycling system, clearing damaged cells and improving overall cellular health.
May reduce inflammation and age-related risks, such as cardiovascular disease, neurodegenerative conditions, and certain cancers.
May enhance brain health, lowering the risk of cognitive decline by reducing neuroinflammation and supporting cellular repair.
May improve immune function, particularly in older adults, by balancing immune response and reducing harmful overactivation.
LONGEVITY DIRECT
A seamless experience, medications delivered straight to your door, online access to experienced US physicians, coaching, testing, optimization, and monitoring – all supported by our unbeatable care.
No waiting rooms, no hidden fees.
All included in your plan.
Science-backed treatments are the cornerstone of any effective longevity program.
Diligently prescribed to suit your needs, your medication targets the underlying mechanisms of aging to help you thrive.
The first longevity wearable to harness the power of biometric AI. Usually $149, included in your plan.
Refining millions of unique longevity signals, it unlocks clear, actionable guidance tailored to your unique longevity profile.
Your all-in-one coach for fitness, nutrition, sleep, and mindfulness.
Powered by data and designed for results, it turns insights into meaningful longevity progress tracking.
For queries related to your medication, our physicians are available to provide clear guidance and support.
They are here to address your concerns and ensure your treatment aligns with your unique health profile.
* Rapamycin is not FDA-approved for the treatment of longevity or anti-aging purposes. Learn more about ‘off-label’ uses.
* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.
* Common side effects of Rapamycin include mouth sores, diarrhea, joint pain, acne, headache, or increased risk of infection. Do not take Rapamycin if you are allergic to it, have liver disease, or have a history of lung or breathing problems.
* Call your doctor immediately if you have symptoms of an allergic reaction such as rash, itching, swelling, severe dizziness, trouble breathing, or symptoms of serious infections.
Access clinically validated medications redefining how we approach aging.
Longevity Direct is an element within Longr’s Longevity OS, a platform dedicated to extending access to longevity.
© 2025 Longr Holdings Inc.
If you’re looking to age better – whether by optimizing your health or addressing early signs of decline – Rapamycin could be a meaningful step forward.
By targeting the mTOR pathway, Rapamycin helps shift your body’s focus from growth to repair, promoting cellular health and reducing inflammation.
Research suggests it may improve immune function, support cognitive health, and lower risks of age-related diseases like cardiovascular decline and cancer.
While Rapamycin is prescribed “off-label” for longevity purposes, it’s backed by extensive studies and careful medical oversight ensures it’s safe and effective.
At Longevity Direct, we tailor your treatment plan through a detailed intake process, supported blēo and The Longevity AI to track your progress.
Once approved, your plan evolves to meet your needs.
Safety
Rapamycin is administered in low, intermittent doses to minimize risks.
Any potential side effects, such as mild digestive upset or temporary immune changes, are rare and manageable with proper care.
Our team ensures you’re supported every step of the way.
Important to know
Rapamycin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Rapamycin is one of the most studied compounds in longevity science, attracting significant interest from researchers worldwide.
With decades of research across organisms from yeast to mammals, it has consistently demonstrated its potential to extend lifespan and improve healthspan.
Proven to extend lifespan:
Rapamycin has extended lifespan in every organism tested, from yeast to mammals, by targeting the mTOR pathway.
(Source: EUROPE PMC)
Improves healthspan:
Rapamycin slows age-related decline, supporting healthier cells and delaying aging-associated conditions.
(Source: EUROPE PMC)
Boosts immune function:
Enhances immune response, particularly in older adults, by promoting cellular repair and reducing inflammation.
Reduces risks of specific conditions:
Cognitive protection:
May slow cognitive decline by reducing neuroinflammation and supporting brain health.
(Source: OXFORD ACADEMIC)
Metabolic health:
Improves insulin sensitivity and reduces systemic inflammation linked to metabolic disorders.
(Source: PLOS JOURNALS)
Organ health:
Protects organs like the kidneys and liver from age-related damage via cellular repair mechanisms.
(Source: PLOS JOURNALS)
Cancer risk reduction:
Slows the progression of certain cancers by inhibiting cell proliferation and activating autophagy.
(Source: PLOS JOURNALS)
Joint and bone health:
Research suggests it may alleviate arthritis symptoms and improve bone density.
(Source: PLOS JOURNALS)
Important to know
Rapamycin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.
Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.
Imagine your body as a city, bustling with activity.
Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.
As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.
This is where Rapamycin comes in.
It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.
Specifically, Rapamycin:
Activates cellular recycling (autophagy):
Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.
Reduces harmful overgrowth:
Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.
Supports stress resilience:
When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.
Temporary immune changes:
Rapamycin can cause mild immunosuppression, making it essential to follow dosing guidelines closely.
Digestive issues:
Some users report mild nausea, diarrhea, or stomach discomfort.
Mouth sores:
A common but manageable side effect, especially at higher doses.
Fatigue or headaches:
Occasionally experienced but typically mild.
With proper medical oversight and careful dosing, these risks are both manageable and avoidable.
At Longevity Direct, our team closely monitors your progress to ensure the safest, most effective treatment plan for your needs.
Important to know
Rapamycin is not FDA-approved for longevity or anti-aging purposes.
Prescriptions are approved through an online consultation with a licensed healthcare provider.