GLP-1 Therapies

The most transformative health breakthrough in a generation.

Semaglutide (the same active ingredient as Wegovy® & Ozempic®) and Tirzepatide (the same active ingredient as Mounjaro® & Zepbound®).

Available as tablets and injectables.  

Starting at $299 / month.

Why GLP-1 Therapies?

The Future of Healthcare

Supports Weight Management

GLP-1 medications are clinically proven to support meaningful weight loss. They work by enhancing satiety, reducing cravings, and promoting better portion control.

Enhances Metabolic Health

GLP-1 therapies improve glucose regulation and insulin sensitivity. These benefits lower fasting blood sugar levels and reduce risks associated with metabolic syndromes.

GLP-1 Benefits

  • General Longevity
    GLP-1 therapies may help reduce risks associated with age-related conditions, promoting a longer, healthier life.

  • Metabolic Optimization
    Improves insulin sensitivity, reduces fasting glucose levels, and enhances overall metabolic efficiency.

  • Cardiovascular Health
    Studies show significant reductions in cardiovascular risks, including hypertension and cholesterol levels.

  • Weight and Fat Reduction
    Promotes effective and sustained weight loss, reducing visceral fat and improving body composition.

  • Cognitive Function
    Emerging research links GLP-1 therapies to reduced neuroinflammation and potential cognitive benefits.

General Longevity
GLP-1 therapies may help reduce risks associated with age-related conditions, promoting a longer, healthier life.

Metabolic Optimization
Improves insulin sensitivity, reduces fasting glucose levels, and enhances overall metabolic efficiency.

Cardiovascular Health
Studies show significant reductions in cardiovascular risks, including hypertension and cholesterol levels.

Weight and Fat Reduction
Promotes effective and sustained weight loss, reducing visceral fat and improving body composition.

Cognitive Function
Emerging research links GLP-1 therapies to reduced neuroinflammation and potential cognitive benefits.

LONGEVITY DIRECT

Your GLP-1 Program

A seamless experience, medications delivered straight to your door, online access to experienced US physicians, coaching, testing, optimization, and monitoring – all supported by our unbeatable care.

No waiting rooms, no hidden fees.

All included in your plan.

Medication

Science-backed treatments are the cornerstone of any effective longevity program.

Diligently prescribed to suit your needs, your medication targets the underlying mechanisms of aging to help you thrive.

The first longevity wearable to harness the power of biometric AI. Usually $149, included in your plan. 

Refining millions of unique longevity signals, it unlocks clear, actionable guidance tailored to your unique longevity profile.

Your all-in-one coach for fitness, nutrition, sleep, and mindfulness.

Powered by data and designed for results, it turns insights into meaningful longevity progress tracking. 

Lab Tests

Understanding your body’s inner workings is the cornerstone of effective longevity planning.
 

All plans include comprehensive and frequent lab testing, which may include CBC, CMP, Lipid Panel, hs-CRP, and Hemoglobin A1c.

Physician On Demand

For queries related to your medication, our physicians are available to provide clear guidance and support.

They are here to address your concerns and ensure your treatment aligns with your unique health profile.

GLP-1

Free shipping | Free medical evaluation
 
  • Monthly shipping options

  • Available as weekly injections or daily oral dissolving tablets (ODTs) for patient convenience

  • Branded and compounded options, including Semaglutide and Tirzepatide

  • Sourced from certified US-based pharmacies

  • Includes routine blood work and ongoing support from licensed physicians 
Free shipping | Free medical evaluation
 

Monthly shipping options

Available as weekly injections or daily oral dissolving tablets (ODTs) for patient convenience

Branded and compounded options, including semaglutide and tirzepatide

Sourced from certified US-based pharmacies

Includes routine blood work and ongoing support from licensed clinicians

* GLP-1 medications are FDA-approved for diabetes and weight management, not explicitly for longevity. Learn more about ‘off-label’ uses.

* Prescription products are subject to healthcare provider approval and require an online consultation with a healthcare provider after checkout who will determine if a prescription is appropriate. Take the medication as directed by your protocols.

* Common side effects of GLP-1s include include nausea, vomiting, constipation, and fatigue. Severe side effects are rare and should be discussed with your provider immediately.

* Call your doctor if you experience serious symptoms such as difficulty breathing, swelling, or signs of infection.

Research

Access clinically validated medications redefining how we approach aging.

What are GLP-1 receptor agonists (Semaglutide and Tirzepatide)?
Studied benefits
of GLP-1s (Semaglutide and Tirzepatide)?
How do Semaglutide and Tirzepatide work?
Potential
side effects

What are GLP-1 receptor agonists (Semaglutide and Tirzepatide)?

GLP-1 receptor agonists, such as Semaglutide (the active ingredient in Wegovy® and Ozempic®) and Tirzepatide (the active ingredient in Mounjaro®), are medications that mimic a natural hormone in your body called glucagon-like peptide-1 (GLP-1)

Originally developed for managing type 2 diabetes, these medications are now recognized for their transformative effects on weight management, metabolic health, and even cognitive function.

Think of GLP-1 as a messenger in your body that ensures everything runs smoothly after meals — like a project manager who keeps energy levels balanced and prevents overindulgence.

GLP-1 receptor agonists amplify this effect, improving your body’s natural ability to regulate blood sugar, control appetite, and burn energy efficiently.

Semaglutide focuses on the GLP-1 pathway, while Tirzepatide is a dual-action therapy that combines GLP-1 with GIP (glucose-dependent insulinotropic polypeptide), like hiring a co-manager to boost productivity even further.

Safety

GLP-1 receptor agonists are generally well-tolerated, particularly when introduced gradually. Common side effects, such as mild nausea or digestive discomfort, are typically temporary and improve as your body adjusts.

Physician oversight ensures that any potential side effects are monitored and managed effectively.

Important to know

GLP-1 receptor agonists are FDA-approved for managing type 2 diabetes and chronic weight management but are not specifically approved for longevity purposes.

All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile and goals.

What are the benefits of Semaglutide and Tirzepatide for Health?

GLP-1 medications are gaining an incredible amount recognition, not just managing conditions like obesity and diabetes, but also enhancing overall health and longevity.

Sustainable weight loss:
These medications consistently support significant and sustained weight loss, which reduces risks for many chronic diseases.

Improved metabolic health:
GLP-1s enhance insulin sensitivity, lower blood sugar levels, and reduce inflammation, combating conditions like type 2 diabetes and metabolic syndrome.

Cardiovascular protection:
Studies have shown reduced heart disease risk, including lower blood pressure and improved cholesterol profiles​

Cognitive support:
Preliminary research suggests benefits for brain health, such as reduced neuroinflammation and potential protection against cognitive decline – including Dementia and Alzheimer’s. 

Important to know

GLP-1 receptor agonists are FDA-approved for managing type 2 diabetes and chronic weight management but are not specifically approved for longevity purposes.

All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile and goals.

How do Semaglutide and Tirzepatide work?

GLP-1 medications, such as Semaglutide (in Wegovy® and Ozempic®) and Tirzepatide (in Mounjaro®), enhance your body’s natural hormonal response to food, helping regulate processes like hunger, digestion, and blood sugar levels.

Imagine your metabolism as a symphony orchestra.

Without a conductor, the players might lose rhythm — leading to chaotic blood sugar spikes, uncontrolled cravings, and inefficient energy use.

GLP-1 acts as the conductor, ensuring every instrument works together in harmony.

Here’s how GLP-1 medications orchestrate balance and health:

Reduce appetite:
GLP-1 interacts with brain centers like the hypothalamus, which regulate hunger and satiety. It signals that you’re full after eating, helping you avoid overeating.

Think of it as flipping the “I’m satisfied” switch sooner, so you feel full with smaller portions.

Slow digestion:
These medications delay how quickly food leaves your stomach, preventing sudden blood sugar spikes and providing a steady release of energy.

It’s like putting your digestive system into “slow release” mode, ensuring a smoother flow of energy instead of a quick sugar rush.

Enhance insulin sensitivity:
GLP-1 improves your body’s response to insulin, the hormone that helps move glucose from your bloodstream into cells for energy. This reduces overall blood sugar levels and inflammation.

Imagine teaching your body to respond better to its insulin, like upgrading from an outdated operating system to a smarter, faster one.

Promote weight loss:
By curbing cravings, reducing caloric intake, and optimizing how your body uses stored fat, GLP-1 medications support sustainable and meaningful weight loss.

It’s like having a coach reminding you to use your energy reserves wisely rather than constantly restocking them.

Reduce inflammation:
Research shows GLP-1 medications may also reduce inflammation in the brain and other tissues, providing potential cognitive and systemic health benefits.

Think of it as a gentle anti-inflammatory mist calming overactive signals throughout your body.

Tirzepatide’s dual-action advantage:
Tirzepatide adds another layer of effectiveness by also targeting GIP, a hormone that works alongside GLP-1 to improve insulin secretion and fat metabolism. This dual approach amplifies benefits like appetite suppression and blood sugar control.

It’s like having two expert conductors leading the same symphony for maximum effect.

What are the potential side effects of Semaglutide and Tirzepatide?

While GLP-1s are generally well-tolerated, they can have side effects. The most common include:

Nausea or vomiting: Especially early in treatment as your body adjusts.

Digestive discomfort: Slower digestion can sometimes cause bloating or constipation.

Injection site reactions (if injectable): These are typically mild and temporary.

Rare but more serious risks include gallbladder issues (e.g., gallstones) and pancreatitis. Careful monitoring ensures these risks remain minimal​.

With proper medical oversight and careful dosing, these risks are both manageable and avoidable. 

At Longevity Direct, we guide you through treatment, addressing any concerns and ensuring you achieve the maximum benefits safely​.

Important to know

GLP-1 receptor agonists are FDA-approved for managing type 2 diabetes and chronic weight management but are not specifically approved for longevity purposes.

All prescriptions are carefully reviewed and tailored by a licensed healthcare provider to align with your health profile and goals.

Contact

Questions, suggestions, reflections?

Fill out the form below and a member of our team well get back to you as soon as possible.

Contact Form (#14)

How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.