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HS-CRP (High-Sensitivity C-Reactive Protein)

LDL Particle Number

Basophils (Absolute)

Lipoprotein(a) [Lp(a)]

Bilirubin (Total and Direct)

SHBG (Sex Hormone Binding Globulin)

Alkaline Phosphatase (ALP)

Monocytes (Absolute)

Neutrophils (Absolute)

Hemoglobin A1C

25(OH)D (25-Hydroxyvitamin D)

GGT (Gamma-Glutamyl Transferase)

ApoA/ApoB Ratio

Creatinine

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

Immature Granulocytes

RBC Magnesium

TPO Ab (Thyroid Peroxidase Antibodies)

AST (Aspartate Aminotransferase)

Apolipoprotein B

Albumin

Fasting Insulin

Uric Acid

Ceruloplasmin

Serum Cortisol

Triglycerides

MCH (Mean Corpuscular Hemoglobin)

Copper Serum

Lymphocytes (Absolute)

VLDL Cholesterol (calculated)

Chloride

BUN (Blood Urea Nitrogen)

MCV (Mean Corpuscular Volume)

Total Cholesterol

Free T3 (Triiodothyronine)

Glucose

Bicarbonate

RDW (Red Cell Distribution Width)

Calcium

IL-6 (Interleukin-6)
TNF-α, a biomarker for longevity, is used to monitor chronic inflammation and age-related diseases. Understanding its levels can aid in personalized health strategies.

TNF-α (Tumor Necrosis Factor-alpha)

TNF-α, also known as Tumor Necrosis Factor-alpha, is a biomarker that has been extensively studied in the context of longevity. Elevated levels of TNF-α have been associated with chronic inflammation, which is a major contributor to the aging process and age-related diseases. As a result, monitoring TNF-α levels can provide valuable insight into an individual’s overall health and potential lifespan. By understanding the role of TNF-α in aging and disease, researchers and healthcare providers can develop targeted interventions to mitigate its effects, ultimately leading to improved longevity and quality of life for individuals.

Biomarker Explained

TNF-α, or Tumor Necrosis Factor-alpha, is a well-studied biomarker that has been linked to longevity and aging. Elevated levels of TNF-α are associated with chronic inflammation, a key factor in the aging process and the development of age-related diseases. Consequently, monitoring TNF-α levels can provide valuable insights into an individual’s overall health and potential lifespan. By understanding the role of TNF-α in aging and disease, researchers and healthcare providers can develop targeted interventions to mitigate its effects, ultimately leading to improved longevity and quality of life for individuals. In practical terms, high levels of TNF-α could indicate an increased risk of age-related diseases and a reduced lifespan, while low levels could suggest a lower risk and potential for an extended lifespan. Therefore, incorporating TNF-α monitoring into routine health assessments can be valuable for assessing and promoting longevity.

Keywords:

TNF-α, Tumor Necrosis Factor-alpha, biomarker, longevity, aging, chronic inflammation, age-related diseases

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Longevity Direct logo in color – promoting personalized longevity insights and AI-driven health optimization

Rapamycin

Metformin

GLP-1

General Longevity
Heart Health
Weight Management
Glucose Control
Cognitive Function
Diabetes Prevention
Mood Support
Energy & Fatigue
Autoimmune Support
Blood Pressure
Chronic Pain & Arthritis
Aging Skin
Men’s Aging
Women’s Aging

Longevity Library
About

get Started
Client portal

Contact

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How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.