ApoA/ApoB Ratio

LDH (Lactate Dehydrogenase)

LDL Particle Number

Uric Acid

LDL Cholesterol (calculated)

ALT (Alanine Aminotransferase)

eGFR (Estimated Glomerular Filtration Rate)

25(OH)D (25-Hydroxyvitamin D)

Alkaline Phosphatase (ALP)

Bicarbonate

IGF-1 (Insulin-Like Growth Factor 1)

Cystatin C

HDL Cholesterol

UIBC (Unsaturated Iron Binding Capacity)

Sed Rate (Erythrocyte Sedimentation Rate)

Vitamin A (Retinol)

Total Cholesterol

Lipoprotein(a) [Lp(a)]

SHBG (Sex Hormone Binding Globulin)

Sodium

Lymphocytes (Absolute)

Apolipoprotein A1

Free T4 (Thyroxine)

HS-CRP (High-Sensitivity C-Reactive Protein)

Homocysteine

Ceruloplasmin

RDW (Red Cell Distribution Width)

Neutrophils (Absolute)

VLDL Cholesterol (calculated)

Hemoglobin

NRBC (Nucleated Red Blood Cells)

ANA (Antinuclear Antibody)

Calcium

MCV (Mean Corpuscular Volume)

Hemoglobin A1C

TPO Ab (Thyroid Peroxidase Antibodies)

WBC (White Blood Cell Count)

BUN (Blood Urea Nitrogen)

Reverse T3 (rT3)

RBC Magnesium

"Creatinine levels can be a valuable biomarker for assessing kidney function and overall health in the context of longevity and aging research."

Creatinine

Creatinine is a valuable biomarker for longevity assessment as it reflects the functionality of the kidneys, an essential organ for overall health and longevity. High levels of creatinine may indicate impaired kidney function, which is a significant risk factor for age-related decline and mortality. Monitoring creatinine levels can provide valuable insights into kidney health and help identify potential areas for intervention to promote longevity. Additionally, changes in creatinine levels over time can offer valuable information about the effectiveness of longevity interventions, making it a critical marker for assessing and improving overall health and lifespan.

Biomarker Explained

Creatinine is one of the most important biomarkers used for longevity assessment. It is primarily used to reflect the functionality of the kidneys, which are crucial organs for overall health and longevity. High levels of creatinine in the body may indicate impaired kidney function, which is a significant risk factor for age-related decline and mortality. Thus, monitoring creatinine levels can provide valuable insights into kidney health and help identify potential areas for intervention to promote longevity. Furthermore, changes in creatinine levels over time can offer valuable information about the effectiveness of longevity interventions. This makes creatinine a critical marker for assessing and improving overall health and lifespan. Therefore, when interpreting creatinine levels, it is important to consider the potential implications for kidney health, age-related decline, and mortality risk. Additionally, understanding and monitoring creatinine levels can provide valuable insights into the effectiveness of longevity interventions, allowing for adjustments to be made to promote optimal health and lifespan.

Keywords:

Biomarker, longevity, creatinine, kidney function, age-related decline, mortality risk, intervention

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How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.