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25(OH)D (25-Hydroxyvitamin D)

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

MCH (Mean Corpuscular Hemoglobin)

Eosinophils (Absolute)

Monocytes (Absolute)

LDL Cholesterol (calculated)

Lymphocytes (Absolute)

MCV (Mean Corpuscular Volume)

Lactic Acid

Triglycerides

RBC Magnesium

Fibrinogen

Ferritin

TIBC (Total Iron Binding Capacity)

Creatinine

TNF-α (Tumor Necrosis Factor-alpha)

AST (Aspartate Aminotransferase)

Lipoprotein(a) [Lp(a)]

WBC (White Blood Cell Count)

NRBC (Nucleated Red Blood Cells)

VLDL Cholesterol (calculated)

GGT (Gamma-Glutamyl Transferase)

HS-CRP (High-Sensitivity C-Reactive Protein)

Reverse T3 (rT3)

LDL Particle Size

LDH (Lactate Dehydrogenase)

BUN (Blood Urea Nitrogen)

Serum Iron

Apolipoprotein B

Total Protein

TPO Ab (Thyroid Peroxidase Antibodies)

Platelet Count

Free T3 (Triiodothyronine)

DHEA-S (Dehydroepiandrosterone Sulfate)

Ceruloplasmin

Potassium

BUN/Creatinine Ratio

SHBG (Sex Hormone Binding Globulin)

RDW (Red Cell Distribution Width)

ApoA/ApoB Ratio
HOMA-IR is a valuable biomarker for assessing insulin resistance, an important factor in longevity and age-related health. Understanding and monitoring HOMA-IR levels can provide insight into the risk of chronic diseases and overall lifespan.

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

HOMA-IR is a valuable biomarker used in longevity research to assess insulin resistance, a key factor in aging and age-related diseases. As a measure of the body’s ability to maintain glucose homeostasis, HOMA-IR provides insight into metabolic health and overall risk of chronic conditions such as diabetes, cardiovascular disease, and cancer. Lower HOMA-IR levels are associated with improved cellular function and longevity, making it an important tool for identifying individuals at higher risk for age-related health issues. By monitoring and optimizing HOMA-IR, researchers and healthcare professionals can better understand and promote healthy aging.

Biomarker Explained

Insulin resistance is a key factor in aging and age-related diseases, and HOMA-IR is a valuable biomarker used in longevity research to assess it. By measuring the body’s ability to maintain glucose homeostasis, HOMA-IR provides insight into metabolic health and overall risk of chronic conditions such as diabetes, cardiovascular disease, and cancer. Lower HOMA-IR levels are associated with improved cellular function and longevity, making it an important tool for identifying individuals at higher risk for age-related health issues. Monitoring and optimizing HOMA-IR can help researchers and healthcare professionals better understand and promote healthy aging by identifying and addressing potential risk factors.

Keywords:

Insulin resistance, HOMA-IR, aging, longevity, biomarker, glucose homeostasis, chronic conditions

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Longevity Direct logo in color – promoting personalized longevity insights and AI-driven health optimization

Rapamycin

Metformin

GLP-1

General Longevity
Heart Health
Weight Management
Glucose Control
Cognitive Function
Diabetes Prevention
Mood Support
Energy & Fatigue
Autoimmune Support
Blood Pressure
Chronic Pain & Arthritis
Aging Skin
Men’s Aging
Women’s Aging

Longevity Library
About

get Started
Client portal

Contact

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How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.