HOMA-IR is a valuable biomarker used in longevity research to assess insulin resistance, a key factor in aging and age-related diseases. As a measure of the body’s ability to maintain glucose homeostasis, HOMA-IR provides insight into metabolic health and overall risk of chronic conditions such as diabetes, cardiovascular disease, and cancer. Lower HOMA-IR levels are associated with improved cellular function and longevity, making it an important tool for identifying individuals at higher risk for age-related health issues. By monitoring and optimizing HOMA-IR, researchers and healthcare professionals can better understand and promote healthy aging.