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Hemoglobin

AST (Aspartate Aminotransferase)

Chloride

Total Testosterone

Basophils (Absolute)

EPA (Eicosapentaenoic Acid)

Apolipoprotein A1

Serum Iron

Lipoprotein(a) [Lp(a)]

TNF-α (Tumor Necrosis Factor-alpha)

Sed Rate (Erythrocyte Sedimentation Rate)

TSH (Thyroid Stimulating Hormone)

Cystatin C

Free Testosterone

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

Iron Saturation

Ferritin

Serum Cortisol

Lymphocytes (Absolute)

Bilirubin (Total and Direct)

ANA (Antinuclear Antibody)

Platelet Count

GGT (Gamma-Glutamyl Transferase)

MCH (Mean Corpuscular Hemoglobin)

ALT (Alanine Aminotransferase)

Alkaline Phosphatase (ALP)

DHEA-S (Dehydroepiandrosterone Sulfate)

Apolipoprotein B

Free T3 (Triiodothyronine)

LDH (Lactate Dehydrogenase)

HDL Cholesterol

25(OH)D (25-Hydroxyvitamin D)

Fasting Insulin

Free T4 (Thyroxine)

LDL Particle Number

WBC (White Blood Cell Count)

Total Cholesterol

Calcium

Uric Acid

Eosinophils (Absolute)
HOMA-IR is a valuable biomarker for assessing insulin resistance, an important factor in longevity and age-related health. Understanding and monitoring HOMA-IR levels can provide insight into the risk of chronic diseases and overall lifespan.

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

HOMA-IR is a valuable biomarker used in longevity research to assess insulin resistance, a key factor in aging and age-related diseases. As a measure of the body’s ability to maintain glucose homeostasis, HOMA-IR provides insight into metabolic health and overall risk of chronic conditions such as diabetes, cardiovascular disease, and cancer. Lower HOMA-IR levels are associated with improved cellular function and longevity, making it an important tool for identifying individuals at higher risk for age-related health issues. By monitoring and optimizing HOMA-IR, researchers and healthcare professionals can better understand and promote healthy aging.

Biomarker Explained

Insulin resistance is a key factor in aging and age-related diseases, and HOMA-IR is a valuable biomarker used in longevity research to assess it. By measuring the body’s ability to maintain glucose homeostasis, HOMA-IR provides insight into metabolic health and overall risk of chronic conditions such as diabetes, cardiovascular disease, and cancer. Lower HOMA-IR levels are associated with improved cellular function and longevity, making it an important tool for identifying individuals at higher risk for age-related health issues. Monitoring and optimizing HOMA-IR can help researchers and healthcare professionals better understand and promote healthy aging by identifying and addressing potential risk factors.

Keywords:

Insulin resistance, HOMA-IR, aging, longevity, biomarker, glucose homeostasis, chronic conditions

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Longevity Direct logo in color – promoting personalized longevity insights and AI-driven health optimization

Rapamycin

Metformin

GLP-1

General Longevity
Heart Health
Weight Management
Glucose Control
Cognitive Function
Diabetes Prevention
Mood Support
Energy & Fatigue
Autoimmune Support
Blood Pressure
Chronic Pain & Arthritis
Aging Skin
Men’s Aging
Women’s Aging

Longevity Library
About

get Started
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How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.