Nucleated Red Blood Cells (NRBC) are a promising biomarker for assessing longevity. These cells, which are typically only found in the bone marrow and are not present in the normal circulation of healthy individuals, have been linked to various age-related diseases and conditions. Elevated levels of NRBCs have been associated with increased mortality and a higher risk of developing cardiovascular disease, cancer, and other chronic illnesses. Monitoring NRBC levels can provide valuable insight into the aging process and overall health status, allowing for early intervention and personalized treatment strategies to promote longevity and healthy aging.