WBC (White Blood Cell Count)

ALT (Alanine Aminotransferase)

DHEA-S (Dehydroepiandrosterone Sulfate)

LDL Cholesterol (calculated)

Total Protein

AST (Aspartate Aminotransferase)

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

LDH (Lactate Dehydrogenase)

TSH (Thyroid Stimulating Hormone)

Total Testosterone

Chloride

Iron Saturation

Homocysteine

TNF-α (Tumor Necrosis Factor-alpha)

TPO Ab (Thyroid Peroxidase Antibodies)

Neutrophils (Absolute)

Bilirubin (Total and Direct)

RDW (Red Cell Distribution Width)

A/G Ratio (Albumin/Globulin Ratio)

Sodium

25(OH)D (25-Hydroxyvitamin D)

Total Cholesterol

Insulin

Potassium

Free T4 (Thyroxine)

Basophils (Absolute)

TIBC (Total Iron Binding Capacity)

GGT (Gamma-Glutamyl Transferase)

Platelet Count

Apolipoprotein B

Creatinine

eGFR (Estimated Glomerular Filtration Rate)

Monocytes (Absolute)

Tg Ab (Thyroglobulin Antibodies)

Sed Rate (Erythrocyte Sedimentation Rate)

Triglycerides

ANA (Antinuclear Antibody)

Albumin

Lactic Acid

LDL Particle Size

Discover the significance of UIBC (Unsaturated Iron Binding Capacity) as a biomarker used to assess oxidative stress and potential implications for longevity.

UIBC (Unsaturated Iron Binding Capacity)

UIBC (Unsaturated Iron Binding Capacity) is a biomarker used in longevity research to assess the body’s ability to transport iron. It measures the amount of iron that can be bound to transferrin, a protein responsible for iron transport in the blood. Low levels of UIBC may indicate iron overload, while high levels could suggest iron deficiency. Maintaining optimal iron levels is important for overall health and longevity, as both excess and deficiency can have negative impacts on various physiological processes. By monitoring UIBC levels, individuals can make informed decisions about their iron intake and supplementation to support their longevity goals.

Biomarker Explained

Unsaturated Iron Binding Capacity (UIBC) is a crucial biomarker used in longevity research to evaluate the body’s ability to transport iron. It measures the amount of iron that can be bound to transferrin, a vital protein responsible for iron transport in the blood. High levels of UIBC may indicate iron deficiency, as the body attempts to increase its ability to bind and transport iron. Conversely, low levels of UIBC could suggest iron overload, as there is less capacity for binding excess iron. Maintaining optimal iron levels is essential for overall health and longevity, as both excessive and deficient iron levels can have negative impacts on various physiological processes. By monitoring UIBC levels, individuals can gain valuable insight into their iron status, and make informed decisions about their iron intake and supplementation to support their longevity goals. Regular monitoring of UIBC, in conjunction with other relevant biomarkers, can provide a comprehensive picture of an individual’s iron metabolism and help guide interventions for optimal health and longevity.

Keywords:

Unsaturated Iron Binding Capacity, UIBC, Longevity research, Iron transport, Transferrin, Iron deficiency, Iron overload, Biomarkers

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How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.