Albumin

Iron Saturation

BUN/Creatinine Ratio

Alkaline Phosphatase (ALP)

MCHC (Mean Corpuscular Hemoglobin Concentration)

Bicarbonate

Glucose

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)

Serum Iron

Bilirubin (Total and Direct)

Ceruloplasmin

UIBC (Unsaturated Iron Binding Capacity)

RDW (Red Cell Distribution Width)

Sed Rate (Erythrocyte Sedimentation Rate)

Triglycerides

Hemoglobin A1C

Tg Ab (Thyroglobulin Antibodies)

SHBG (Sex Hormone Binding Globulin)

Insulin

LDL Particle Number

DHA (Docosahexaenoic Acid)

EPA (Eicosapentaenoic Acid)

DHEA-S (Dehydroepiandrosterone Sulfate)

BUN (Blood Urea Nitrogen)

Hematocrit

TIBC (Total Iron Binding Capacity)

RBC Magnesium

LDL Particle Size

LDH (Lactate Dehydrogenase)

TNF-α (Tumor Necrosis Factor-alpha)

Lipoprotein(a) [Lp(a)]

eGFR (Estimated Glomerular Filtration Rate)

IL-6 (Interleukin-6)

IGF-1 (Insulin-Like Growth Factor 1)

TPO Ab (Thyroid Peroxidase Antibodies)

ALT (Alanine Aminotransferase)

Calcium

Free Testosterone

Cystatin C

Free T3 (Triiodothyronine)

Discover the significance of eGFR as a biomarker for longevity. Understand its role in assessing kidney function and overall health for longevity.

eGFR (Estimated Glomerular Filtration Rate)

eGFR is a crucial biomarker in assessing kidney function and overall health, particularly in the context of longevity. As the kidneys play a vital role in filtering waste and maintaining fluid balance, a lower eGFR can indicate decreased kidney function and potential health risks. Monitoring eGFR can help identify individuals at risk for chronic kidney disease, cardiovascular disease, and other age-related conditions. By tracking eGFR levels, healthcare professionals can intervene early with lifestyle and medical interventions to potentially slow the progression of age-related decline and improve overall longevity.

Biomarker Explained

eGFR, or estimated glomerular filtration rate, is a crucial biomarker in assessing kidney function and overall health, particularly in the context of longevity. The kidneys play a vital role in filtering waste and maintaining fluid balance, and a lower eGFR can indicate decreased kidney function and potential health risks. When monitoring eGFR, healthcare professionals can identify individuals at risk for chronic kidney disease, cardiovascular disease, and other age-related conditions. By tracking eGFR levels, they can intervene early with lifestyle and medical interventions to potentially slow the progression of age-related decline and improve overall longevity. Therefore, a higher eGFR is generally indicative of better kidney function and overall health, while a lower eGFR may signal the need for further medical intervention and lifestyle adjustments to promote longevity.

Keywords:

eGFR, estimated glomerular filtration rate, kidney function, longevity, chronic kidney disease, cardiovascular disease, age-related conditions

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How does Rapaymcin work?

Rapamycin slows aging by targeting the mTOR pathway, shifting the body’s focus from growth to repair. It promotes cellular recycling, reduces overgrowth linked to disease, and enhances resilience to stress.

Imagine your body as a city, bustling with activity.

Cells are the workers, and mTOR (mechanistic target of rapamycin) is the city planner, deciding where to focus resources – building new structures, cleaning up waste, or repairing old ones.

As we age, mTOR often prioritizes building (cell growth) over maintenance (cellular repair), leading to “clutter” in our bodies that contributes to aging and disease.

This is where Rapamycin comes in.

It acts like a wise advisor to mTOR, convincing it to slow down unnecessary growth projects and focus on clean up and repair instead.

Specifically, Rapamycin:

Activates cellular recycling (autophagy):

Think of autophagy as the city’s waste management system. Damaged parts of cells are broken down and reused, keeping the system efficient and healthy.

Reduces harmful overgrowth:

Overactive mTOR has been linked to diseases such as cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer’s. By dialing back excessive growth signals, Rapamycin helps prevent these issues.

Supports stress resilience:

When cells are less focused on growing, they’re better equipped to handle stress, repair damage, and maintain long-term health.